Table 3 Abilities of antigens to differentiate between TB disease and no TB disease after re-evaluation with the validation ELISA.
Antigen | TB cases | HHCs | P-value | AUC | Cut-off Value | Sensitivity (%) | Specificity (%) |
|---|---|---|---|---|---|---|---|
Rv0867c | 1.0 (0-43.8) | 25.5 (0-257.5) | 0.009 | 0.78 | > 29.3 | 47 (7/15 | 93 (14/15) |
Rv1009 | 0.6 (0-27.1) | 9.8 (0-273.4) | 0.012 | 0.77 | < 1.4 | 53 (8/15) | 87 (13/15) |
Rv2389c | 0.4 (0-29.5) | 23.6 (0-297.4) | 0.005 | 0.80 | < 0.1 | 40 (6/15) | 93 (14/15) |
Rv0081 | 0.2 (0-400.0) | 1.3 (0-97.1) | 0.146 | 0.65 | < 0.1 | 20 (3/15) | 93 (14/15) |
Rv1996 | 0.8 (0-33.7) | 0 (0-195.4) | 0.771 | 0.53 | > 7.6 | 20 (3/15) | 93 (14/15) |
Rv2032 | 0.5 (0-21.0) | 1.3 (0-400.0) | 0.120 | 0.67 | < 0.1 | 47 (7/15) | 86 (12/14) |
Rv2624c | 0 (0-3.7) | 0 (0-1.7) | 0.295 | 0.61 | < 0.1 | 27 (4/15) | 93 (14/15) |
Rv2625c | 0.3 (0-31.4) | 1.3 (0-400.0) | 0.262 | 0.62 | < 0.1 | 47 (7/15) | 87 (13/15) |
ESAT-6/CFP-10 | 305 (0-400.0) | 308 (0-400.0) | 0.712 | 0.53 | > 441.2 | 33 (5/15) | 96 (26/28) |