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Table 3 Abilities of antigens to differentiate between TB disease and no TB disease after re-evaluation with the validation ELISA.

From: Potential of novel Mycobacterium tuberculosis infection phase-dependent antigens in the diagnosis of TB disease in a high burden setting

Antigen TB cases HHCs P-value AUC Cut-off Value Sensitivity
(%)
Specificity
(%)
Rv0867c 1.0 (0-43.8) 25.5 (0-257.5) 0.009 0.78 > 29.3 47 (7/15 93 (14/15)
Rv1009 0.6 (0-27.1) 9.8 (0-273.4) 0.012 0.77 < 1.4 53 (8/15) 87 (13/15)
Rv2389c 0.4 (0-29.5) 23.6 (0-297.4) 0.005 0.80 < 0.1 40 (6/15) 93 (14/15)
Rv0081 0.2 (0-400.0) 1.3 (0-97.1) 0.146 0.65 < 0.1 20 (3/15) 93 (14/15)
Rv1996 0.8 (0-33.7) 0 (0-195.4) 0.771 0.53 > 7.6 20 (3/15) 93 (14/15)
Rv2032 0.5 (0-21.0) 1.3 (0-400.0) 0.120 0.67 < 0.1 47 (7/15) 86 (12/14)
Rv2624c 0 (0-3.7) 0 (0-1.7) 0.295 0.61 < 0.1 27 (4/15) 93 (14/15)
Rv2625c 0.3 (0-31.4) 1.3 (0-400.0) 0.262 0.62 < 0.1 47 (7/15) 87 (13/15)
ESAT-6/CFP-10 305 (0-400.0) 308 (0-400.0) 0.712 0.53 > 441.2 33 (5/15) 96 (26/28)
  1. Median levels of IFN-γ (pg/ml) and ranges (in parentheses) detected in supernatants from TB cases (n = 15) and household contacts (n = 15) after evaluation with the Quantiferon TB Gold ELISA are shown. IFN-γ values were corrected for the unstimulated control levels and responses > 10 IU/ml (400 pg/ml) were given a value of 400 pg/ml. AUC = Area under the ROC curve