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Table 1 IC50 values of seven extracts in P. falciparum and other microbes.

From: High content live cell imaging for the discovery of new antimalarial marine natural products

 

3D7

MRSA

VREF

WTCA

ARCA

G-0005-4

0.680 ± 0.13

NT

16.4

227

156

G-0021-3

0.790 ± 0.17

11.9

15.2

> 250

250

G-0049-4

0.916 ± 0.19

8.5

7.1

221

225

G-0335-3

0.775 ± 0.25

62.5

> 250

> 250

> 250

G-0355-3

0.131 ± 0.02

1.9

69.2

> 250

> 250

G-0488-3

0.119 ± 0.03

0.5

> 250

1.08

1.11

G-0490-3

0.163 ± 0.02

1.26

67.61

> 250

> 250

G-0494-4

0.137 ± 0.02

0.5

0.5

> 250

> 250

G-0580-3

0.0055 ± 0.01

92.26

153.11

> 250

> 250

G-0588A-3

0.847 ± 0.09

39.9

107.5

150

150

  1. Extracts are considered a 'hit' if IC50 < 100 μg/mL, and extracts with > 250 μg/mL are considered not active. IC50 values for 3D7 P. falciparum strain are significantly lower than other microbes (MRSA: methicillin-resistant Staphylococcus aureus; VREF: vancomycin- resistant Enterococcus faecium; WTCA: wild type Candida albicans; ARCA: amphotericin-B-resistant Candida albicans). NT indicates not tested, values for P. falciparum 3D7 samples are from duplicates, and the values for MRSA, VREF, WTCA, or ARCA screens are from a single experiment. Unit values are in μg/mL.