Table 1 Demographic characteristics and nasopharyngeal carriage in children with AOM and healthy controls
From: Risk factors for serotype 19A carriage after introduction of 7-valent pneumococcal vaccination
Total N = 3507 n (%) | Healthy controls N = 909 Total n (%) | Children with AOM N = 2598 Total n (%) | p | |
|---|---|---|---|---|
Demographic characteristics | ||||
Sex M | 1818 (51.8) | 442 (48.6) | 1376 (53) | 0.02 |
Mean age ± SD (months) | 13.6 ± 5.2 | 13.1 ± 5.4 | 13.8 ± 5.1 | 0.0008 |
Vaccination with PCV7* | 3448 (98.3) | 890 (97.9) | 2558 (98.5) | 0.2 |
Partial | 754 (21.9) | 149 (16.7) | 605 (23.7) | |
Complete | 2693 (78.1) | 741 (83.3) | 1952 (76.3) | |
Type of care | <0.0001 | |||
Day care centre | 1170 (33.4) | 138 (15.2) | 1032 (39.7) | |
Childminder | 1127 (32.1) | 316 (34.8) | 811 (31.2) | |
Home | 1209 (34.5) | 455 (50.1) | 754 (29.1) | |
Siblings | 1906 (54.3) | 420 (46.2) | 1486 (57.2) | <0.0001 |
Use of Antibiotics 3 months before | 1439 (41.0) | 195 (21.5) | 1244 (47.9) | <0.0001 |
Nasopharyngeal carriage | ||||
S. pneumoniae | 1780 (50.8) | 270 (29.7) | 1510 (58.1) | <0.0001 |
Penicillin susceptibility** | 0.0001 | |||
Susceptible | 974 (54.9) | 182 (68.2) | 792 (52.6) | |
Intermediate | 732 (41.3) | 76 (28.5) | 656 (43.5) | |
Resistant | 67 (3.8) | 9 (3.3) | 58 (3.9) | |
Haemophilus influenzae | 1399 (39.9) | 130 (14.3) | 1269 (48.8) | <0.0001 |
Moraxella catarrhalis | 1780 (50.8) | 301 (33.1) | 1479 (56.9) | <0.0001 |
Staphylococcus aureus | 235 (6.7) | 99 (10.9) | 136 (5.2) | <0.0001 |
Multiple carriage (ie at least two species) | 1715 (48.9) | 213 (23.4) | 1502 (57.8) | <0.0001 |
No bacteria identified | 563 (16.1) | 376 (41.4) | 187 (7.2) | <0.0001 |