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Table 3 Clinical features and diagnoses of 37 infants with confirmed RSV disease.

From: Reduced Dicer expression in the cord blood of infants admitted with severe respiratory syncytial virus disease

 

MILD DISEASE

SEVERE DISEASE

Sig.

   Number

17

20

-

CLINICAL FEATURES:

     

   Significant Dyspnea1

0

(0%)

17

(85%)

-

   Apnea

0

(0%)

2

(10%)

-

   Cardiovascular Compromise

0

(0%)

2

(10%)

-

   Highest pCO2, mean (S.D.), kPa

5.83

(0.93)

6.70

(1.88)

p = 0.0882

   Lowest O2 saturation; mean (S.D.), %

98

(2.4)

93

(5.9)

p = 0.0052

   Highest Respiratory Rate; Mean (S.D.),/min

40

(9.7)

50

(8.3)

p = 0.0032

   Pulse on admission; mean (S.D.),/min

153

(18)

155

(18)

p = 0.8062

   Weight on admission; mean (S.D.), grams

6470

(1613)

6640

(1910)

p = 0.822

   Duration of symptoms on admission; mean (S.D.), days

4.5

(3.4)

4.1

(1.3)

p = 0.622

   Length of stay; median (IQR), days

2

(2 - 4)

5

(3 - 5)

p = 0.0013

INTERVENTIONS

     

   CPAP/Ventilator

0

(0%)

0

(0%)

-

   Supplemental Oxygen

0

(0%)

8

(40%)

-

   Supplemental Fluids

     

Intravenous

0

(0%)

2

(10%)

-

Feeding Tube

0

(0%)

3

(15%)

-

CLINICAL DIAGNOSIS:5

     

   Bronchiolitis

12

(71%)

20

(100%)

 

   Pneumonia

1

(6%)

2

(10%)

 

   Atelectasis

0

(0%)

2

(10%)

p = 0.4074

   URTI

1

(6%)

0

(0%)

 

   Uncertain Diagnosis6

4

(24%)

0

(0%)

-

  1. Note: There was a statistically significant reduction in oxygen saturation, increase in respiratory rate and longer length of stay in the severe disease group, and a tendency to higher pCO2. Clinical features, interventions and diagnoses incorporated in the algorithm for disease severity were not analyzed statistically. pCO2: capillary partial pressure of carbon dioxide; URTI = Upper respiratory tract infection.
  2. 1 Pediatrician's assessment of respiratory effort.
  3. 2 Student's t-test; 3Mann-Whitney test; 4chi-square test.
  4. 5 Some patients received more than one diagnosis, e.g.: bronchiolitis and atelectasis.
  5. 6 4 patients tested for RSV by GPs, but not referred to hospital, received an uncertain diagnosis. An inquiry of hospital archives reveals that these patients have not been admitted at other pediatric clinics in our region.