Enhanced upper genital tract pathologies by blocking Tim-3 and PD-L1 signaling pathways in mice intravaginally infected with Chlamydia muridarum

Table 1 Incidence of gross pathologies

Group	Total mice	No of mice			Total oviducts	No of oviducts with hydrosalpinx scores
		None	Uni	Bi		0	1	2	3	4	Total score
Isotype control	10	2	0	8	20	4	2	2	5	7*	49
αTim-3+ αPD-L1	10	0	1	9	20	1	2	0	3	14*	67

*p = 0.028
Mice were sacrificed 60 days after infection and the reproductive tissues were isolated and inspected for gross pathologies (see Figure 2 for images). Number of mice without (none) or with hydrosalpinx on single (Uni) or both (Bi) sides of the reproductive tissues was listed on the left portion of the table. Number of oviducts without (0) or with varying severity degrees (1 to 4) of hydrosalpinx was listed on the right portion of the table. Fisher Exact test was used to compare the differences in incidences of mouse with hydrosalpinx or oviducts with varying degrees of hydrosalpinx between the control and antibody treatment groups. P-vales with statistic differences were marked. * stands for p < 0.05.

ISSN: 1471-2334