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Table 1 Demographic information and clinical manifestations of patients with hand, foot, and mouth disease from July through December 2010

From: An outbreak of coxsackievirus A6 hand, foot, and mouth disease associated with onychomadesis in Taiwan, 2010

  CA6 infection (N = 130) Non-CA6 infection (N = 145) P*
Median age in years (range) 2 (0-44) 3 (0-13) 0.16
Male/female 81/49 89/56 0.90
Hospitalization 70 (54%) 59 (41%) 0.03
Intensive care unit stay 0 2 (1%) 0.50
Fever 106 (82%) 121 (83%) 0.87
Eruption around the oral area 28 (22%) 7 (5%) <0.001
Eruption at the trunk and/or neck 39 (30%) 24 (17%) 0.01
Desquamation 66 (51%) 28 (19%) <0.001
Nail abnormalities** 48 (37%) 7 (5%) <0.001
  1. *P values were measured using the Mann-Whitney U test for age, Fisher's exact test for intensive care unit stay, and chi-square test for the other parameters. CA6 denotes coxsackievirus A6. **Nail abnormalities included Beau's line, defined as transverse ridging of the nail plate, or onychomadesis, defined as nail separation starting at the matrix, which may extend distally to the proximal portion of the nail bed.