| Logistic regression model Outcome: immunovirological success | Cox regression model Outcome: switch from first-line therapy | ||
---|---|---|---|---|
 | Adjusted odds ratio with 95%CI | p value | Adjusted hazard ratio with 95%CI | p value |
Age (years) | Â | Â | Â | Â |
   ≥ 50 | 2.03 (0.66-6.23) | 0.214 | 1.83 (1.02-3.31) | 0.044 |
   < 50 | reference category |  | reference category |  |
Transmission | Â | Â | Â | Â |
   Heterosexual | reference category |  | reference category |  |
   men who have sex with men | 1.54 (0.52-4.56) | 0.433 | 0.87 (0.47-1.60) | 0.653 |
   IVDU/infected blood | 0.72 (0.09-5.38) | 0.746 | 0.60 (0.14-2.66) | 0.503 |
HIV clinical stage | Â | Â | Â | Â |
   AIDS | reference category |  | reference category |  |
   non-AIDS | 0.70 (0.26-1.85) | 0.475 | 1.13 (0.86-1.50) | 0.382 |
Baseline CD4+ (T cells/μL) |  |  |  |  |
   < 100/μL | reference category |  | reference category |  |
   ≥ 100/μL | 2.93 (1.16-7.39) | 0.023 | 1.00 (0.75-1.33) | 0.997 |
Baseline HIV-RNA (copies/mL, log 10 ) | Â | Â | Â | Â |
   ≥ 5 log10/mL | reference category |  | reference category |  |
   < 5 log10/mL | 1.73 (0.56-5.38) | 0.344 | 0.92 (0.65-1.29) | 0.628 |
First-line therapy | Â | Â | Â | Â |
   NNRTIs | reference category |  | reference category |  |
   Unboosted PIs * | 1.25 (0.25-6.25) | 0.788 | 3.88 (1.40-10.7) | 0.009 |
   Boosted PIs ** | 0.78 (0.25-2.41) | 0.663 | 4.21 (1.70-10.4) | 0.002 |