Table 3 Gene ontology categories and pathways over-represented for the proteins shown in the network in Figure 1C and 1D (level 2 interactions), according to DAVID

Blood coagulation

2.50E-18

CXCL2, STK39, SERPING1, MAPK9, LMAN1, MAPK1, HSPA5, F10, MAPK11, PLG, MDK, HMGB1, EGFR, PRKCG, PLAT, THBS1, F3, MAPK13, F2R, PRNP, BCL2, HSP90AA1, ALDOB, SERPINF2, VWF, OXSR1, MAP2K1, ALB, C7, RPS6KA5, MAPKAPK5, PRKCA, F8, PROC, KNG1, NF1, TFPI2, GRM7, CLU, SERPINE1, SFN, PLA2G7, TLK2, MAPK14, C8B, XRCC6, GNA12, SERPINC1, APTX, MMP25, C9, TRIB3, F2, TMOD1, FN1, F2RL1, PLAU, BMPR1B, TLK1, CEBPB, APOH, HSPA8, COL1A, BAX, PROS1, TF, VCP, F9, GNA13

Regulation of body fluid levels

3.30E-16

SERPING1, LMAN1, F2R, F8, PROC, KNG1, F2, F10, TFPI2, F2RL1, VWF, SERPINE1, PLG, PLAU, APOH, PLAT, PROS1, GNA12, THBS1, F3, F9, SERPINC1, GNA13

Cell death

4.90E-13

PRKCZ, MAPK1, HSPA, NEB, CALR, PLG, HMGB1, MARK4, PRKCG, MAP3K7, PPARD, F2R, PRNP, BCL2, APP, RAF1, C7, ALB, IGFBP3, BCL2L1, PRKCA, ATN1, PROC, KNG1, NF1, PAK1, CLU, SFN, MCL1, BAK1, SIAH1, C8B, SNCA, BCL2L10, APTX, TRAF6, C9, TUBB, F2, TRIB3, STK4, PAX3, SMAD3, CEBPB, RTN4, BAX, ATXN1, VCP, MMP9

Response to wounding

2.70E-16

CXCL2, SERPING1, LMAN1, PRKCA, F8, KNG1, PROC, F10, NF1, TFPI2, SERPINE1, CLU, PLG, MDK, PLA2G7, C8B, PLAT, F3, THBS1, GNA12, SERPINC1, F2R, MMP25, C9, F2, SERPINF2, FN1, F2RL1, VWF, PLAU, BMPR1B, CEBPB, APOH, C7, BAX, TF, PROS1, F9, GNA13

Acute inflammatory response

8.50E-07

SERPING1, CLU, F8, C9, F2, CEBPB, C7, TF, C8B, SERPINF2, FN1

PATHWAYS

p-VALUE

GENES

Complement and coagulation cascades

8.90E-14

SERPING1, F2R, C9, F8, PROC, KNG1, F2, F10, SERPINF2, VWF, SERPINE1, PLG, PLAU, C7, CPB2, PROS1, PLAT, C8B, F3, F9, SERPINC1

MAPK signaling pathway

1.90E-08

MAPKAPK5, MAPK9, PRKCA, MAPK1, NF1, MKNK1, PAK1, MAPK11, PRKCB1, CHUK, EGFR, MAPK14, PRKCG, MAP3K7, GNA12, MYC, TRAF6, MAPK13, RPS6KA1, STK4, TGFBR2, MAP3K14, MAP2K1, NGFB, IKBKB, RAF1, RPS6KA5, TGFBR1, PRKACA, MAPK3

TGF-beta signaling pathway

4.60E-07

SMAD2, SMAD9, SMURF1, SMAD6, MAPK1, TGFBR2, RHOA, BMPR1B, SMAD3, SMAD1, TGFBR1, MAPK3, THBS1, SMAD5, SMAD4, MYC

Focal adhesion

2.10E-05

LAMA1, LAMA5, MAPK9, PRKCA, MAPK1, BCL2, SRC, FN1, PAK1, VWF, RHOA, ERBB2, PRKCB1, MAP2K1, RAF1, EGFR, COL1A1, PRKCG, THBS1, MAPK3, LAMA3

Adherens junction

5.20E-05

SMAD2, TGFBR2, ERBB2, RHOA, MAPK1, SRC, SMAD3, EGFR, TGFBR1, MAP3K7, MAPK3, SMAD4

Toll-like receptor signaling pathway

9.30E-04

MAPK9, MAPK11, MAPK3, MAPK13, TRAF6, MAPK1, CHUK, MAP2K1, IKBKB, MAPK14, IRAK1, AP3K7, MAPK3