Table 2 Comparison of 163 Patients with Methicillin-Resistant Staphylococcus aureus Bacteremia, by Vancomycin Minimum Inhibitory Concentration.
Variable | MIC (ug/mL) | ||
|---|---|---|---|
≤ 1 (n = 51) | ≥ 2 (n = 112) | p | |
Age, years, median (range) | 54 (26-95) | 59 (23-92) | .115 |
Female gender | 23 (45.1) | 60 (53.6) | .316 |
White race | 22 (43.1) | 51 (45.5) | .775 |
Congestive heart failure | 10 (19.6) | 25 (22.3) | .696 |
Coronary artery disease | 11 (21.6) | 26 (23.2) | .817 |
Chronic obstructive pulmonary diseases | 15 (29.4) | 22 (19.6) | .167 |
Renal function | |||
Normal | 36 (70.6) | 81 (72.3) | Ref.c |
Chronic renal insufficiency without dialysis | 4 (7.8) | 10 (8.9) | .866 |
Chronic renal insufficiency with dialysis | 11 (21.6) | 21 (18.8) | .697 |
Malignancy | 10 (19.6) | 25 (22.3) | .696 |
HIV infection | 4 (7.8) | 3 (2.7) | .206 |
Chronic skin disease | 5 (9.8) | 8 (7.1) | .547 |
Peripheral vascular diseases | 4 (7.8) | 7 (6.3) | .741 |
Diabetes mellitus | 27 (52.9) | 34 (30.4) | .006 |
Systemic corticosteroid use last 28 days | 9 (17.6) | 15 (13.4) | .477 |
Cirrhosis | 4 (7.8) | 10 (8.9) | 1.00 |
History of intravenous drug use | 4 (7.8) | 11 (9.8) | .778 |
History of smoking | 29 (56.9) | 67 (58.9) | .865 |
Any transplant | 2 (3.9) | 8 (7.1) | .726 |
Surgery during hospitalization | 10 (19.6) | 13 (11.6) | .174 |
Prosthetic joint | 4 (7.8) | 11 (9.8) | .778 |
Vascular graft | 9 (17.6) | 14 (12.5) | .381 |
Cardiac device | 4 (7.8) | 6 (5.4) | .506 |
ICU admission within 48 hours after the first positive blood culture | 19 (37.3) | 40 (35.7) | .849 |
Central venous catheterization at the time of the first (+) blood culture | 37 (72.5) | 77 (68.8) | .624 |
Onset | |||
Community-associated | 4 (7.8) | 8 (7.1) | Ref.c |
Healthcare-associated community onset | 32 (62.7) | 66 (58.9) | .962 |
Healthcare-associated hospital onset | 15 (29.4) | 38 (33.9) | .730 |
Site of MRSA bacteremia | |||
Primary bacteremia | 25 (49.0) | 45 (40.2) | Refc |
Catheter related bloodstream infection | 12 (23.5) | 25 (22.3) | .344 |
Skin infection | 8 (15.7) | 17 (15.2) | .508 |
Postoperative surgical site infection | 2 (3.9) | 12 (10.7) | .552 |
Other | 4 (7.8) | 13 (11.6) | .520 |
Any metastatic infection at the time of diagnosis | 6 (11.8) | 17 (15.2) | .562 |
Outcome | |||
Recurrent MRSA infection (n = 161) a, b | 10/51 (19.6) | 16/110 (14.5) | .417 |
Death at 28 days after diagnosis of bacteremia | 9 (17.6) | 26 (23.2) | .422 |