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Table 1 Clinical and laboratory manifestations of 53 haematological patients with Mycobacterium tuberculosis (TB) infection

From: Clinical characteristics and outcomes of Mycobacterium tuberculosis disease in adult patients with hematological malignancies

 

Total (n= 53)

Neutropenia

Sites of tuberculosis

  

No (n= 27)

Yes (n= 26)

P value

Pulmonary TB only (n= 38)

Extra-pulmonary involvemente (n= 15)

P value

Elderly

   

0.28

  

0.24

Age more than 60 year

25

15

10

 

20

5

 

Age less than 60 year

28

12

16

 

18

10

 

Gender

   

0.56

  

0.34

Male

37

20

17

 

28

9

 

Female

16

7

9

 

10

6

 

Underlying Diabetes mellitus

   

0.67

  

0.66

Yes

6

4

2

 

5

1

 

No

47

23

24

 

33

14

 

Hematological Disease

   

0.013

  

0.76

Acute myeloid leukemia

29

10

19

 

20

9

 

Non-Acute myeloid leukemia

24

17

7

 

18

6

 

Diagnosis of tuberculosis and malignancy

   

0.001

  

0.33

Synchronousa

17

3

14

 

14

3

 

Non-synchronous

36

24

12

 

24

12

 

Allogeneic stem cell transplantation

   

0.19

  

> 0.99

Yes

6

5

1

 

4

2

 

No

47

25

22

 

34

13

 

Defeverence within 72 hoursb

   

0.55

  

0.030

Yes

17

9

8

 

15

2

 

No

31

13

18

 

18

13

 

Extra-pulmonary tuberculosis

   

> 0.99

   

Yes

38

19

19

    

No

15

8

7

    

Laboratory datac

Absolute neutrophil count (/uL) at fever

1970

3587

198

0.019

2174

1100

0.87

Absolute neutrophil count (/uL) at nadir

39

761

17

< 0.001

39

39

0.59

Albumin (g/dL)

3.60

3.48

3.70

0.40

3.50

3.6

0.80

Serum alanine aminotransferase (IU/L)

30

26

34

0.67

34

27

0.44

Alkaline phosphatase (IU/L)

174

207

141

0.06

175

153

0.52

Lactate dehydrogenase (IU/L)

509

574

440

0.96

509

509

0.58

C-reactive protein (mg/dL)

5.42

5.43

5.16

0.60

5.59

4.73

0.48

Treatmentd

Standard therapy

39

20

19

> 0.99

31

8

0.048

Fluoroquinolone based therapy

9

4

5

 

4

5

 

Outcome (30 days)

Death

3

1

2

0.61

0

3

0.019

Alive

50

26

24

 

38

12

 
  1. aSynchronous define as diagnosis of tuberculosis within 3 months of hematological malignancy
  2. bFive patients with pulmonary tuberculosis did not present with fever
  3. cMedian Value
  4. d48 patients received anti-tuberculosis treatment
  5. eFive of the 15 patients (33.3%) with extra-pulmonary tuberculosis (lymph node, 2; liver aspirates, 1; urine, 1; and blood, 1) also had documented pulmonary tuberculosis