| Total (n= 53) | Neutropenia | Sites of tuberculosis | ||||
---|---|---|---|---|---|---|---|
 |  | No (n= 27) | Yes (n= 26) | P value | Pulmonary TB only (n= 38) | Extra-pulmonary involvemente (n= 15) | P value |
Elderly | Â | Â | Â | 0.28 | Â | Â | 0.24 |
Age more than 60 year | 25 | 15 | 10 | Â | 20 | 5 | Â |
Age less than 60 year | 28 | 12 | 16 | Â | 18 | 10 | Â |
Gender | Â | Â | Â | 0.56 | Â | Â | 0.34 |
Male | 37 | 20 | 17 | Â | 28 | 9 | Â |
Female | 16 | 7 | 9 | Â | 10 | 6 | Â |
Underlying Diabetes mellitus | Â | Â | Â | 0.67 | Â | Â | 0.66 |
Yes | 6 | 4 | 2 | Â | 5 | 1 | Â |
No | 47 | 23 | 24 | Â | 33 | 14 | Â |
Hematological Disease | Â | Â | Â | 0.013 | Â | Â | 0.76 |
Acute myeloid leukemia | 29 | 10 | 19 | Â | 20 | 9 | Â |
Non-Acute myeloid leukemia | 24 | 17 | 7 | Â | 18 | 6 | Â |
Diagnosis of tuberculosis and malignancy | Â | Â | Â | 0.001 | Â | Â | 0.33 |
Synchronousa | 17 | 3 | 14 | Â | 14 | 3 | Â |
Non-synchronous | 36 | 24 | 12 | Â | 24 | 12 | Â |
Allogeneic stem cell transplantation | Â | Â | Â | 0.19 | Â | Â | > 0.99 |
Yes | 6 | 5 | 1 | Â | 4 | 2 | Â |
No | 47 | 25 | 22 | Â | 34 | 13 | Â |
Defeverence within 72 hoursb | Â | Â | Â | 0.55 | Â | Â | 0.030 |
Yes | 17 | 9 | 8 | Â | 15 | 2 | Â |
No | 31 | 13 | 18 | Â | 18 | 13 | Â |
Extra-pulmonary tuberculosis | Â | Â | Â | > 0.99 | Â | Â | Â |
Yes | 38 | 19 | 19 | Â | Â | Â | Â |
No | 15 | 8 | 7 | Â | Â | Â | Â |
Laboratory datac | |||||||
Absolute neutrophil count (/uL) at fever | 1970 | 3587 | 198 | 0.019 | 2174 | 1100 | 0.87 |
Absolute neutrophil count (/uL) at nadir | 39 | 761 | 17 | < 0.001 | 39 | 39 | 0.59 |
Albumin (g/dL) | 3.60 | 3.48 | 3.70 | 0.40 | 3.50 | 3.6 | 0.80 |
Serum alanine aminotransferase (IU/L) | 30 | 26 | 34 | 0.67 | 34 | 27 | 0.44 |
Alkaline phosphatase (IU/L) | 174 | 207 | 141 | 0.06 | 175 | 153 | 0.52 |
Lactate dehydrogenase (IU/L) | 509 | 574 | 440 | 0.96 | 509 | 509 | 0.58 |
C-reactive protein (mg/dL) | 5.42 | 5.43 | 5.16 | 0.60 | 5.59 | 4.73 | 0.48 |
Treatmentd | |||||||
Standard therapy | 39 | 20 | 19 | > 0.99 | 31 | 8 | 0.048 |
Fluoroquinolone based therapy | 9 | 4 | 5 | Â | 4 | 5 | Â |
Outcome (30 days) | |||||||
Death | 3 | 1 | 2 | 0.61 | 0 | 3 | 0.019 |
Alive | 50 | 26 | 24 | Â | 38 | 12 | Â |