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Table 1 Clinical and laboratory manifestations of 53 haematological patients with Mycobacterium tuberculosis (TB) infection

From: Clinical characteristics and outcomes of Mycobacterium tuberculosis disease in adult patients with hematological malignancies

  Total (n= 53) Neutropenia Sites of tuberculosis
   No (n= 27) Yes (n= 26) P value Pulmonary TB only (n= 38) Extra-pulmonary involvemente (n= 15) P value
Elderly     0.28    0.24
Age more than 60 year 25 15 10   20 5  
Age less than 60 year 28 12 16   18 10  
Gender     0.56    0.34
Male 37 20 17   28 9  
Female 16 7 9   10 6  
Underlying Diabetes mellitus     0.67    0.66
Yes 6 4 2   5 1  
No 47 23 24   33 14  
Hematological Disease     0.013    0.76
Acute myeloid leukemia 29 10 19   20 9  
Non-Acute myeloid leukemia 24 17 7   18 6  
Diagnosis of tuberculosis and malignancy     0.001    0.33
Synchronousa 17 3 14   14 3  
Non-synchronous 36 24 12   24 12  
Allogeneic stem cell transplantation     0.19    > 0.99
Yes 6 5 1   4 2  
No 47 25 22   34 13  
Defeverence within 72 hoursb     0.55    0.030
Yes 17 9 8   15 2  
No 31 13 18   18 13  
Extra-pulmonary tuberculosis     > 0.99    
Yes 38 19 19     
No 15 8 7     
Laboratory datac
Absolute neutrophil count (/uL) at fever 1970 3587 198 0.019 2174 1100 0.87
Absolute neutrophil count (/uL) at nadir 39 761 17 < 0.001 39 39 0.59
Albumin (g/dL) 3.60 3.48 3.70 0.40 3.50 3.6 0.80
Serum alanine aminotransferase (IU/L) 30 26 34 0.67 34 27 0.44
Alkaline phosphatase (IU/L) 174 207 141 0.06 175 153 0.52
Lactate dehydrogenase (IU/L) 509 574 440 0.96 509 509 0.58
C-reactive protein (mg/dL) 5.42 5.43 5.16 0.60 5.59 4.73 0.48
Treatmentd
Standard therapy 39 20 19 > 0.99 31 8 0.048
Fluoroquinolone based therapy 9 4 5   4 5  
Outcome (30 days)
Death 3 1 2 0.61 0 3 0.019
Alive 50 26 24   38 12  
  1. aSynchronous define as diagnosis of tuberculosis within 3 months of hematological malignancy
  2. bFive patients with pulmonary tuberculosis did not present with fever
  3. cMedian Value
  4. d48 patients received anti-tuberculosis treatment
  5. eFive of the 15 patients (33.3%) with extra-pulmonary tuberculosis (lymph node, 2; liver aspirates, 1; urine, 1; and blood, 1) also had documented pulmonary tuberculosis