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Table 3 Adjusted hazard ratios for death during hospitalization from final regression model stratified according to whether or not patient received initial ceftriaxone therapy.

From: Clinical outcome of pneumococcal meningitis during the emergence of pencillin-resistant Streptococcus pneumoniae: an observational study

Characteristics Initial ceftriaxone therapy (N = 247) Initial antibiotic other than ceftriaxone (N = 164)
  Adjusted Hazard Ratio (95% CI) a
Age category   
   <1 years 3.44 (1.58-7.48) 2.55 (1.21-5.39) b
   1-4 years 4.16 (1.67-10.38)  
   5-14 years 2.61 (0.86-7.94) 1.0b
   15-50 years 1.0  
   >50 years 1.72 (0.63-4.68) 2.61 (1.07-6.39)
Clinical presentation   
Coma on admission 2.42 (1.36-4.30) 2.82 (1.43-5.56)
Laboratory values   
Blood leukocyte count < 15,000 cells/μL 4.38 (2.33-8.25) 2.68 (1.26-5.69)
CSF protein >300 mg/dLc 2.72 (1.44-5.14) 1.19 (0.45-3.15)
Pneumococcal isolate resistant to penicillind 1.68 (1.02-2.76) 1.37 (0.65-2.89)
Serotype 14 0.48 (0.25-0.90) 0.52 (0.14-1.93)
  1. NOTE: CI, confidence interval; MIC, minimal inhibitory concentration.
  2. a Hazard ratios and 95% confidence intervals from multivariable Cox proportional hazards model including age category, presence of coma, CSF protein >300 mg/dL, blood leukocyte count <15,000 cells/μL, penicillin MIC >0.06 μg/ml and serotype 14.
  3. b For patients who received initial antibiotic therapy other than ceftriaxone, age categories for <1 and 1-4 years, and for 5-14 and 15-50 years were combined.
  4. c CSF protein measured at time of admission; data missing for 12 case patients.
  5. d Defined as penicillin MIC >0.06 μg/ml for a pneumococcal isolate from a patient with meningitis.