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Table 3 Factors associated with negative test results of both T-SPOT.TB and TST

From: Improved sensitivity of an interferon-gamma release assay (T-SPOT.TB™) in combination with tuberculin skin test for the diagnosis of latent tuberculosis in the presence of HIV co-Infection

Variable Univariate analysis Multivariate analysis
   OR 95% CI p-value Adjusted OR 95% CI p-value
Age, per 10 years older 2.93 1.24-6.91 0.014 3.07 1.22-7.74 0.017
Female 0.96 0.20-4.52 0.073 2.22 0.33-14.7 0.409
Body mass index, per 5 kg/m2 increase 1.71 0.62-4.69 0.300    
Non-white ethnicity 0.22 0.04-1.55 0.092 - - -
Risk Men who have sex with men 1* - - - - -
  Heterosexual 0.25 0.15-1.14 0.134 - - -
  Intravenous drug use 0.67 0.13-3.45 0.629 - - -
Prior AIDS-defining condition 3.35 0.87-13.0 0.080 3.02 0.56-16.2 0.198
Antiretroviral treatment 1.24 0.31-4.96 0.764 0.71 0.13-4.01 0.699
CD4 cell count, per 50 cells/μL increase 0.86 0.70-1.04 0.123 - - -
CD4 cell count ≥200 versus < 200 cells/μL 0.41 0.11-1.46 0.168 0.46 0.10-2.05 0.306
CD8 cell count, per 50 cells/μL increase 1.01 0.96-1.05 0.740 - - -
Extrapulmonary versus pulmonary TB 1.22 0.34-4.32 0.759 - - -
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