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Table 3 Factors associated with negative test results of both T-SPOT.TB and TST

From: Improved sensitivity of an interferon-gamma release assay (T-SPOT.TB™) in combination with tuberculin skin test for the diagnosis of latent tuberculosis in the presence of HIV co-Infection

Variable

Univariate analysis

Multivariate analysis

  

OR

95% CI

p-value

Adjusted OR

95% CI

p-value

Age, per 10 years older

2.93

1.24-6.91

0.014

3.07

1.22-7.74

0.017

Female

0.96

0.20-4.52

0.073

2.22

0.33-14.7

0.409

Body mass index, per 5 kg/m2 increase

1.71

0.62-4.69

0.300

   

Non-white ethnicity

0.22

0.04-1.55

0.092

-

-

-

Risk

Men who have sex with men

1*

-

-

-

-

-

 

Heterosexual

0.25

0.15-1.14

0.134

-

-

-

 

Intravenous drug use

0.67

0.13-3.45

0.629

-

-

-

Prior AIDS-defining condition

3.35

0.87-13.0

0.080

3.02

0.56-16.2

0.198

Antiretroviral treatment

1.24

0.31-4.96

0.764

0.71

0.13-4.01

0.699

CD4 cell count, per 50 cells/μL increase

0.86

0.70-1.04

0.123

-

-

-

CD4 cell count ≥200 versus < 200 cells/μL

0.41

0.11-1.46

0.168

0.46

0.10-2.05

0.306

CD8 cell count, per 50 cells/μL increase

1.01

0.96-1.05

0.740

-

-

-

Extrapulmonary versus pulmonary TB

1.22

0.34-4.32

0.759

-

-

-