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Table 2 Multilocus sequence types and antimicrobial efflux mechanisms in 2005 quinolone-resistant isolates

From: Rapid evolution of fluoroquinolone-resistant Escherichia coli in Nigeria is temporally associated with fluoroquinolone use

QREC Strain MLST ST ST Complex fliC type Resistance
Profile
Nalidixic acid MIC (μg/ml) Organic solvent tolerance Nalidixic acid fold inhibition with PAβN Δ GyrA Δ ParC Transcription fold change-tolC Efflux pump genes with transcription fold change ≥ 4 Efflux regulator genes with transcription fold change 2-8 Efflux regulator genes with transcription fold change > 8
01A 10 10 A A NSLTR 32 + 4 S83L - 2.0 emrK - rob
05C 10 10 B NS TR 4 ++ 8 - - 1.0 mdtA - -
23A 10 10 B AC NSLTR 4 ++ 8 - - 2.0 mdtA marA, soxS, beaS, marR, acrR -
33A 10 10 B AC NSLTR 4 ++ 8 - - 4.5 acrA, acrD, acrE, bcr, cusB, emrA, emrD, emrK, fsr, marA, soxS, evgA, marR, acrR rob, baeS
25A 10 10 D A NSLTR 4 ++ 8 - - 16.8 acrA, acrD, acrE, bcr, cusB, emrA,emrD, emrK, fsr, macA, mdfA, mdtA evgA marA, soxS, rob, beaS, marR, acrR
40B 10 10 E N 4 +++ 8 - - 1.0 - - -
16A 34 10 E NS 4 +++ 16 - - 4.2 acrA, acrD, acrE, bcr, cusB, fsr, mdtA marA, soxS, rob, marR, acrR baeS
49A 43 10 F N 4 + 8 S83L - 2.2 - - -
23B 10 10 C C N LTR 4   8 - - 2.2 - - -
31A 494 none C A NSLTR 4 ++ 8 - - 2.2 acrD, acrE, bcr, emrA, mdtA baeS -
38C 521 none C NS R 4 ++ 8 - - 4.3 acrA, acrD, acrE, bcr, cusB, emrA, emrD, fsr, mdfA, mdtA marA, soxS, evgA, rob, marR, acrR beaS,
22A 452 none C NSLTR 4 + 8 - - 1.1 - - -
31B 452 none C NSLTR 4 - 4 - - 2.5 - - -
33B 504 none K NSLT 1024 +++ 16 S83L - 1.0 - - -
34B 498 467 G NS 4 ++ 8 - - 2.1 - baeS -
32C 503 13 H NSLTR 4 ++ 8 - - 1.0 - baeS -
30A 156 156 I AC NSLTR 4 ++ 16 - - 4.3 acrA, acrD, cusB, emrA, emrK, mdfA soxS, baeS -
27A 448 448 J ACPNSLTR 1024 +++ 2 S83L, D87N S80I 33.2 acrA, acrD, acrE, bcr, cusB, emrA, emrD, fsr, macA, mdfA, mdtA - marA, soxS, evgA, rob, beaS, marR, acrR
09C 517 none L AC NSLTR 4 ++ 8 - - 8.6 acrA, acrD, acrE, bcr, cusB, emrA,emrD, emrK, fsr, mdfA, mdtA marA, soxS, evgA, rob, marR, acrR beaS
38A 517 none N A NSLTR 4 ++ 8 - - 4.2 acrR, acrD, acre, bcr, cusB, fsr, mdtA marA, soxS, evgA, rob, baeS, marR, acrR  
ATCC 25922 ND ND ND - 2 - 8 ND ND 0.4 - - -
NCTC10418 ND ND ND - 2 - 4 ND ND 2.1 - - -
  1. ND: Not Determined
  2. Antimicrobials: A, ampicillin; C, chloramphenicol; P, ciprofloxacin; N, nalidixic acid; S, streptomycin; L, sulfonamides; T, tetracycline; R, trimethoprim