Table 1 Sequential serological, biochemical and virological findings in an HIV-infected individual with markers of prior HBV infection at baseline.
Characteristics | Date (month/year) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
10/85 | 11/87 | 10/001 | 01/011 | 05/011 | 11/061 | 01/071 | 01/081 | 05/09 | 12/09 | 02/10 | 02/10 | 03/10 | 04/10 | 05/10 | 07/10 | |
HBsAg (IU/ml) | NEG | NEG | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | -- | 168 | 183 | 132 | 66 | 0.1 | 0.0 |
Anti-HBs (mIU/ml) | POS | POS | <10 | <10 | <10 | <10 | <10 | <10 | <10 | -- | 140 | 124 | 87 | 61 | 50 | 24 |
Anti-HBc | POS | POS | POS | POS | POS | POS | POS | POS | POS | -- | POS | POS | POS | -- | POS | POS |
Anti-HBc IgM | NEG | NEG | -- | -- | -- | -- | -- | -- | -- | -- | POS | POS | POS | NEG | -- | -- |
HBeAg | NEG | NEG | -- | -- | -- | -- | -- | -- | -- | -- | POS | NEG | NEG | -- | -- | -- |
Anti-HBe | NEG | NEG | -- | -- | -- | -- | -- | -- | -- | -- | POS | POS | POS | -- | -- | -- |
HBV DNA (IU/ml) | -- | -- | R (3) | R (7) | 19 | NR | NR | NR | NR | -- | 88,185 | 5,622 | 998 | 26 | R (4) | NR |
AST (U/l) | 17 | 19 | 31 | 58 | 30 | 20 | 21 | 23 | 28 | 80 | 2,702 | 143 | 41 | -- | 23 | 19 |
ALT (U/l) | 14 | 16 | 35 | 68 | 37 | 14 | 14 | 14 | 19 | 111 | 2,577 | 306 | 42 | -- | 17 | 21 |
CD4+ T (cells/µl) | 891 | 883 | 48 | 29 | 48 | 478 | 580 | 516 | 513 | 304 | 291 | -- | -- | -- | 423 | 333 |
HIV-RNA 2 (copies/ml) | -- | -- | 147,018 | 222,107 | 146,707 | <50 | <50 | NR | NR | 80,558 | -- | -- | 734 | -- | NR | NR |
Antiretroviral therapy | Naive | Naive | No3 | No3 | No3 | Yes4 | Yes4 | Yes4 | Yes4 | No5 | No5 | Yes6 | Yes6 | Yes6 | Yes6 | Yes6 |