Skip to main content

Table 3 Laboratorial characteristics among cases and controls.

From: Factors associated with paradoxical immune response to antiretroviral therapy in HIV infected patients: a case control study

  Cases (n = 39a) Controls (n = 160a) Bivariate analysis
Laboratorial characteristics n (%) n (%) p-valuec OR CI 95%
Lymphopenia prior to first HAART    0.026b 2.6 1.0-6.5
Yes
No
10 (25.6)
19 (48.7)
22 (13.7)
112 (70)
   
Lymphopenia prior to current HAART    0.007b 3.4 1.3-8.8
Yes
No
10 (25.6)
18 (46.1)
16 (10)
100 (62.5)
   
CD4-count prior to the first HAARTd (cells/mm3) 119.2 ± 104.5 Median: 82.5 (IQR: 19-215) 189.1 ± 87.4 Median: 206
(IQR: 122.7-47.7)
0.001b   
HIVVL prior to first HAARTd (copies/ml) 96 251 ± 110 029 Median: 54 193 (IQR: 33 250-117 647) 263 711 ± 501 872 Median: 104 192 (IQR: 19 766-330 500) 0.294   
Logarithm of HIVVL prior to the use of the first HAARTd 4.7 ± 0.4 Median: 4.7 (IQR: 4.5-5) 5 ± 0.7
Median: 5.1
(IQR: 4.3-5.5)
0.547   
CD4-count prior to the current HAARTd (cells/mm3) 125.2 ± 109.4 Median: 119 (IQR: 19-190) 288.2 ± 237.5 Median: 225 (IQR: 164-321) 0.000b   
HIVVL prior to the current HAARTd
(copies/ml)
90 725 ± 114 158 Median: 54 192 (IQR: 9 360-117 647) 125 178 ± 168 825 Median: 47 800 (IQR: 16 413-205 773) 0.487   
Logarithm of HIVVL prior to the current HAARTd 4.4 ± 0.9 Median: 4.7
(IQR: 3.9-5)
4.6 ± 1
Median: 4.8
(IQR: 4.2-5.4)
0.842   
Nadir CD4-countd (cells/mm3) 85.3 ± 68.1 Median: 80.5 (IQR: 19-127.2) 177.8 ± 87.8 Median: 202
(IQR: 109.5-239.5)
0.000b   
Time of undetectable HIVVLd (months) 9.2 ± 4.2 Median: 9.5 (IQR: 5-12.2) 28.8 ± 21.3
Median: 26.5
(IQR: 12.7-35.7)
0.000b   
Time of HIVVL below 1,000 copies/mld (months) 18.8 ± 20.3 Median: 12 (IQR: 8-20.2) 38.9 ± 25.2 Median: 28
(IQR: 22.2-65.2)
0.000b   
  1. n, number; OR, odds ratio; CI 95%, confidence interval of 95%; HAART, highly active antiretroviral therapy; CD4, CD4 Lymphocyte Count; HIVVL, HIV viral load; Nadir CD4-count, the lowest CD4 ever presented by patient; Undetectable HIVVL, over time the most common limit of detection was less than 400 copies/ml.
  2. a different totals are due to missing data.
  3. b p-value < 0,050.
  4. c Chi-square test or Fisher's exact test were used for comparison of categorical variables between the two groups, as more appropriate. For continuous variables, "Student's" T test was used for comparison of normal distributions between the two groups. For non-normal distributions, it was used the Mann-Whitney test.
  5. d Continuous data are represented by mean ± standard deviation and by median with interquartile range (IQR).