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Table 3 Laboratorial characteristics among cases and controls.

From: Factors associated with paradoxical immune response to antiretroviral therapy in HIV infected patients: a case control study

 

Cases (n = 39a)

Controls (n = 160a)

Bivariate analysis

Laboratorial characteristics

n (%)

n (%)

p-valuec

OR

CI 95%

Lymphopenia prior to first HAART

  

0.026b

2.6

1.0-6.5

Yes

No

10 (25.6)

19 (48.7)

22 (13.7)

112 (70)

   

Lymphopenia prior to current HAART

  

0.007b

3.4

1.3-8.8

Yes

No

10 (25.6)

18 (46.1)

16 (10)

100 (62.5)

   

CD4-count prior to the first HAARTd (cells/mm3)

119.2 ± 104.5 Median: 82.5 (IQR: 19-215)

189.1 ± 87.4 Median: 206

(IQR: 122.7-47.7)

0.001b

  

HIVVL prior to first HAARTd (copies/ml)

96 251 ± 110 029 Median: 54 193 (IQR: 33 250-117 647)

263 711 ± 501 872 Median: 104 192 (IQR: 19 766-330 500)

0.294

  

Logarithm of HIVVL prior to the use of the first HAARTd

4.7 ± 0.4 Median: 4.7 (IQR: 4.5-5)

5 ± 0.7

Median: 5.1

(IQR: 4.3-5.5)

0.547

  

CD4-count prior to the current HAARTd (cells/mm3)

125.2 ± 109.4 Median: 119 (IQR: 19-190)

288.2 ± 237.5 Median: 225 (IQR: 164-321)

0.000b

  

HIVVL prior to the current HAARTd

(copies/ml)

90 725 ± 114 158 Median: 54 192 (IQR: 9 360-117 647)

125 178 ± 168 825 Median: 47 800 (IQR: 16 413-205 773)

0.487

  

Logarithm of HIVVL prior to the current HAARTd

4.4 ± 0.9 Median: 4.7

(IQR: 3.9-5)

4.6 ± 1

Median: 4.8

(IQR: 4.2-5.4)

0.842

  

Nadir CD4-countd (cells/mm3)

85.3 ± 68.1 Median: 80.5 (IQR: 19-127.2)

177.8 ± 87.8 Median: 202

(IQR: 109.5-239.5)

0.000b

  

Time of undetectable HIVVLd (months)

9.2 ± 4.2 Median: 9.5 (IQR: 5-12.2)

28.8 ± 21.3

Median: 26.5

(IQR: 12.7-35.7)

0.000b

  

Time of HIVVL below 1,000 copies/mld (months)

18.8 ± 20.3 Median: 12 (IQR: 8-20.2)

38.9 ± 25.2 Median: 28

(IQR: 22.2-65.2)

0.000b

  
  1. n, number; OR, odds ratio; CI 95%, confidence interval of 95%; HAART, highly active antiretroviral therapy; CD4, CD4 Lymphocyte Count; HIVVL, HIV viral load; Nadir CD4-count, the lowest CD4 ever presented by patient; Undetectable HIVVL, over time the most common limit of detection was less than 400 copies/ml.
  2. a different totals are due to missing data.
  3. b p-value < 0,050.
  4. c Chi-square test or Fisher's exact test were used for comparison of categorical variables between the two groups, as more appropriate. For continuous variables, "Student's" T test was used for comparison of normal distributions between the two groups. For non-normal distributions, it was used the Mann-Whitney test.
  5. d Continuous data are represented by mean ± standard deviation and by median with interquartile range (IQR).
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BMC Infectious Diseases

ISSN: 1471-2334

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