Table 5 Scenario 2: Cumulative fraction of response (CFR) for achieving conservative* pharmacodynamic indice exposures for prescribed antimicrobial regimens against outpatient respiratory isolates
ANTIBIOTIC | Dosing Regimen | S. pneumoniae | H. influenzae | M. catharralis |
|---|---|---|---|---|
AMOXICILLIN | 875 mg BID | 95.5% | 86.9% | 14.6% |
AMOXICILLIN | 500 mg TID | 96.3% | 87.8% | 14.8% |
AMOXICILLIN-CLAVULANIC ACID | 875 mg BID | 95.5% | 97.8% | 99.7% |
AMOXICILLIN-CLAVULANIC ACID | 500 mg TID | 96.3% | 99.4% | 100.0% |
AZITHROMICIN | 1000 mg QD | 91.8% | 99.2% | 100.0% |
AZITHROMICIN | 500 mg QD | 91.3% | 67.9% | 99.9% |
CEFACLOR | 750 mg BID | 58.6% | -- | -- |
CEFACLOR | 500 mg BID | 45.5% | -- | -- |
CEFACLOR | 375 mg BID | 35.4% | -- | -- |
CEFACLOR | 250 mg BID | 22.0% | -- | -- |
GATIFLOXACIN | 400 mg QD | 100.0% | 100.0% | 100.0% |
LEVOFLOXACIN | 500 mg QD | 51.4% | 100.0% | 100.0% |
LEVOFLOXACIN | 250 mg QD | 6.6% | 100.0% | 100.0% |
MOXIFLOXACIN | 400 mg QD | 100.0% | 100.0% | 100.0% |