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Table 5 Scenario 2: Cumulative fraction of response (CFR) for achieving conservative* pharmacodynamic indice exposures for prescribed antimicrobial regimens against outpatient respiratory isolates

From: Pharmacodynamic evaluation of commonly prescribed oral antibiotics against respiratory bacterial pathogens

ANTIBIOTIC Dosing Regimen S. pneumoniae H. influenzae M. catharralis
AMOXICILLIN 875 mg BID 95.5% 86.9% 14.6%
AMOXICILLIN 500 mg TID 96.3% 87.8% 14.8%
AMOXICILLIN-CLAVULANIC ACID 875 mg BID 95.5% 97.8% 99.7%
AMOXICILLIN-CLAVULANIC ACID 500 mg TID 96.3% 99.4% 100.0%
AZITHROMICIN 1000 mg QD 91.8% 99.2% 100.0%
AZITHROMICIN 500 mg QD 91.3% 67.9% 99.9%
CEFACLOR 750 mg BID 58.6% -- --
CEFACLOR 500 mg BID 45.5% -- --
CEFACLOR 375 mg BID 35.4% -- --
CEFACLOR 250 mg BID 22.0% -- --
GATIFLOXACIN 400 mg QD 100.0% 100.0% 100.0%
LEVOFLOXACIN 500 mg QD 51.4% 100.0% 100.0%
LEVOFLOXACIN 250 mg QD 6.6% 100.0% 100.0%
MOXIFLOXACIN 400 mg QD 100.0% 100.0% 100.0%
  1. * Beta-lactams = 30% fT > MIC; Azithro = total AUC/MIC ≥ 10; Fluoroquinolones fAUC/MIC ≥ 33.7