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Table 4 Scenario 1: Cumulative fraction of response (CFR) for achieving aggressive* pharmacodynamic indice exposures for prescribed antimicrobial regimens against outpatient respiratory isolates

From: Pharmacodynamic evaluation of commonly prescribed oral antibiotics against respiratory bacterial pathogens

ANTIBIOTIC

Dosing Regimen

S. pneumoniae

H. influenzae

M. catharralis

AMOXICILLIN

875 mg BID

88.2%

69.1%

4.8%

AMOXICILLIN

500 mg TID

91.2%

82.1%

7.4%

AMOXICILLIN-CLAVULANIC ACID

875 mg BID

88.2%

76.1%

88.8%

AMOXICILLIN-CLAVULANIC ACID

500 mg TID

91.2%

91.9%

98.5%

AZITHROMICIN

1000 mg QD

91.3%

46.8%

99.6%

AZITHROMICIN

500 mg QD

76.50%

7.8%

81.4%

CEFACLOR

750 mg BID

17.0%

--

--

CEFACLOR

500 mg BID

9.8%

--

--

CEFACLOR

375 mg BID

6.1%

--

--

CEFACLOR

250 mg BID

2.6%

--

--

GATIFLOXACIN

400 mg QD

100.0%

100.0%

100.0%

LEVOFLOXACIN

500 mg QD

51.4%

100.0%

100.0%

LEVOFLOXACIN

250 mg QD

6.6%

100.0%

100.0%

MOXIFLOXACIN

400 mg QD

100.0%

100.0%

100.0%

  1. * Beta-lactams = 50% fT > MIC; Azithro = total AUC/MIC ≥ 25; Fluoroquinolones fAUC/MIC ≥ 33.7