Table 4 Scenario 1: Cumulative fraction of response (CFR) for achieving aggressive* pharmacodynamic indice exposures for prescribed antimicrobial regimens against outpatient respiratory isolates
ANTIBIOTIC | Dosing Regimen | S. pneumoniae | H. influenzae | M. catharralis |
|---|---|---|---|---|
AMOXICILLIN | 875 mg BID | 88.2% | 69.1% | 4.8% |
AMOXICILLIN | 500 mg TID | 91.2% | 82.1% | 7.4% |
AMOXICILLIN-CLAVULANIC ACID | 875 mg BID | 88.2% | 76.1% | 88.8% |
AMOXICILLIN-CLAVULANIC ACID | 500 mg TID | 91.2% | 91.9% | 98.5% |
AZITHROMICIN | 1000 mg QD | 91.3% | 46.8% | 99.6% |
AZITHROMICIN | 500 mg QD | 76.50% | 7.8% | 81.4% |
CEFACLOR | 750 mg BID | 17.0% | -- | -- |
CEFACLOR | 500 mg BID | 9.8% | -- | -- |
CEFACLOR | 375 mg BID | 6.1% | -- | -- |
CEFACLOR | 250 mg BID | 2.6% | -- | -- |
GATIFLOXACIN | 400 mg QD | 100.0% | 100.0% | 100.0% |
LEVOFLOXACIN | 500 mg QD | 51.4% | 100.0% | 100.0% |
LEVOFLOXACIN | 250 mg QD | 6.6% | 100.0% | 100.0% |
MOXIFLOXACIN | 400 mg QD | 100.0% | 100.0% | 100.0% |