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Table 4 Scenario 1: Cumulative fraction of response (CFR) for achieving aggressive* pharmacodynamic indice exposures for prescribed antimicrobial regimens against outpatient respiratory isolates
| ANTIBIOTIC | Dosing Regimen | S. pneumoniae | H. influenzae | M. catharralis |
|---|---|---|---|---|
| AMOXICILLIN | 875 mg BID | 88.2% | 69.1% | 4.8% |
| AMOXICILLIN | 500 mg TID | 91.2% | 82.1% | 7.4% |
| AMOXICILLIN-CLAVULANIC ACID | 875 mg BID | 88.2% | 76.1% | 88.8% |
| AMOXICILLIN-CLAVULANIC ACID | 500 mg TID | 91.2% | 91.9% | 98.5% |
| AZITHROMICIN | 1000 mg QD | 91.3% | 46.8% | 99.6% |
| AZITHROMICIN | 500 mg QD | 76.50% | 7.8% | 81.4% |
| CEFACLOR | 750 mg BID | 17.0% | -- | -- |
| CEFACLOR | 500 mg BID | 9.8% | -- | -- |
| CEFACLOR | 375 mg BID | 6.1% | -- | -- |
| CEFACLOR | 250 mg BID | 2.6% | -- | -- |
| GATIFLOXACIN | 400 mg QD | 100.0% | 100.0% | 100.0% |
| LEVOFLOXACIN | 500 mg QD | 51.4% | 100.0% | 100.0% |
| LEVOFLOXACIN | 250 mg QD | 6.6% | 100.0% | 100.0% |
| MOXIFLOXACIN | 400 mg QD | 100.0% | 100.0% | 100.0% |
