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Table 4 Scenario 1: Cumulative fraction of response (CFR) for achieving aggressive* pharmacodynamic indice exposures for prescribed antimicrobial regimens against outpatient respiratory isolates

From: Pharmacodynamic evaluation of commonly prescribed oral antibiotics against respiratory bacterial pathogens

ANTIBIOTIC Dosing Regimen S. pneumoniae H. influenzae M. catharralis
AMOXICILLIN 875 mg BID 88.2% 69.1% 4.8%
AMOXICILLIN 500 mg TID 91.2% 82.1% 7.4%
AMOXICILLIN-CLAVULANIC ACID 875 mg BID 88.2% 76.1% 88.8%
AMOXICILLIN-CLAVULANIC ACID 500 mg TID 91.2% 91.9% 98.5%
AZITHROMICIN 1000 mg QD 91.3% 46.8% 99.6%
AZITHROMICIN 500 mg QD 76.50% 7.8% 81.4%
CEFACLOR 750 mg BID 17.0% -- --
CEFACLOR 500 mg BID 9.8% -- --
CEFACLOR 375 mg BID 6.1% -- --
CEFACLOR 250 mg BID 2.6% -- --
GATIFLOXACIN 400 mg QD 100.0% 100.0% 100.0%
LEVOFLOXACIN 500 mg QD 51.4% 100.0% 100.0%
LEVOFLOXACIN 250 mg QD 6.6% 100.0% 100.0%
MOXIFLOXACIN 400 mg QD 100.0% 100.0% 100.0%
  1. * Beta-lactams = 50% fT > MIC; Azithro = total AUC/MIC ≥ 25; Fluoroquinolones fAUC/MIC ≥ 33.7
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