Pharmacodynamic evaluation of commonly prescribed oral antibiotics against respiratory bacterial pathogens

BMC Infectious Diseases

Table 3 MIC distributions for S. pneumoniae, H. influenza, and M. catharralis included in the study

	Percentage (%) of bacteria at each MIC value (mg/L)
Bacterial group (n) and antimicrobial	0.008	0.016	0.032	0.06	0.125	0.25	0.5	1	2	4	8	16	32	> 32
S. pneumoniae (103)
Penicillin	2.9	27.2	24.3	18.4	7.8	5.8	1.0	9.7	2.9	0.0	0.0	0.0	0.0	0.0
Amoxicillin	0.0	1.0	64.1	17.5	2.9	1.9	1.0	1.0	7.8	1.9	1.0	0.0	0.0	0.0
Co-amoxiclav	0.0	1.0	64.1	17.5	2.9	1.9	1.0	1.0	7.8	1.9	1.0	0.0	0.0	0.0
Cefaclor	0.0	0.9	0.0	1.9	4.6	36.1	37.0	5.6	1.9	1.9	0.9	0.9	5.6	2.8
Azithromycin	0.0	0.0	7.8	63.1	20.4	0.0	0.0	0.0	0.0	0.0	1.9	1.0	0.0	5.8
Levofloxacin	0.0	0.0	0.0	0.0	0.0	0.0	14.6	80.6	4.9	0.0	0.0	0.0	0.0	0.0
Gatifloxacin	0.0	0.0	0.0	0.0	2.9	79.6	17.5	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Moxifloxacin	0.0	0.0	0.0	10.7	71.8	17.5	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
H. influenzae (98)
Penicillin	0.0	0.0	0.0	0.0	55.1	16.3	11.2	5.1	0.0	0.0	3.1	4.1	5.1	0.0
Amoxicillin	0.0	0.0	0.0	0.0	7.1	51.0	19.4	8.2	2.0	3.1	0.0	0.0	9.2	0.0
Co-amoxiclav	0.0	0.0	0.0	0.0	9.2	44.9	30.6	12.2	3.1	0.0	0.0	0.0	0.0	0.0
Azithromycin	0.0	0.0	0.0	0.0	3.1	5.1	24.5	44.9	21.4	1.0	0.0	0.0	0.0	0.0
Levofloxacin	30.6	66.3	2.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Gatifloxacin	0.0	96.9	2.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Moxifloxacin	11.2	67.3	18.4	2.0	1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
M. catharralis (29)
Amoxicillin	0.0	0.0	0.0	0.0	0.0	0.0	0.0	6.9	6.9	13.8	24.1	27.6	20.7	0.0
Co-amoxiclav	0.0	0.0	0.0	0.0	51.7	41.4	6.9	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Azithromycin	0.0	0.0	0.0	96.6	0.0	3.4	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Levofloxacin	0.0	0.0	93.1	6.9	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Gatifloxacin	0.0	20.7	75.9	3.4	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Moxifloxacin	0.0	0.0	34.5	65.5	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

ISSN: 1471-2334