Table 2 Representative M. leprae recombinant antigens examined by comparative genomics and actual immune responses.
From: Immunologically reactive M. leprae antigens with relevance to diagnosis and vaccine development
| Â | Â | % Amino acid identity and orthologous genes 1 | Number of Predicted epitopes2 | Immunogenicity specificity 3 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Predicted Function | Size (aa) | M. ulcerans | M. avium | M. bovis(BCG) | M. marinum | M. tuberculosis | T cell | B cell | WBA IFNγ | Ab |
ML0405 | hypothetical protein | 394 | 29 (MUL_5045) | - | 62 (BCG_3680c) | 57 (MMAR_4515) | 62 (Rv3616c) | 7 | 39 | +/+ | +/+ |
ML2331 | possible secreted protein | 256 | 81 (MUL_4308) | 80 (MAV_0385) | 82 (BCG_3777) | 81 (MMAR_5233) | 81 (Rv3717) | 4 | 24 | +/+ | +/+ |
ML2055 | fibronectin attachment protein | 287 | 65 (MUL_3017) | 57 (MAV_2859) | 67 (BCG_1896) | 65 (MMAR_2737) | 67(Rv1860) | 6 | 15 | +/+ | +/+ |
ML1685 | 3-isopropylmalate dehydratase | 476 | 86 (MUL_1968) | 88 (MAV_3838) | 88 (BCG_3009c) | 88 (MMAR_1726) | 88 (Rv2988c) | 3 | 25 | +/+ | - |
ML1632 | possible hydrolase | 511 | 73 (MUL_1334) | 77 (MAV_2243) | 75 (BCG_2040c) | 74 (MMAR_3295) | 75 (Rv2223c) | 4 | 32 | +/+ | - |
ML1556 | initiation factor IF-2 | 924 | 83 (MUL_2122) | 81 (MAV_3693) | 83 (BCG_2859c) | 82 (MMAR_1894) | 83 (Rv2839c) | 3 | 17 | +/+ | - |
ML2044 | Possible glycosyl hydrolase (pseudogene) | 73 | - | - | - | - | - | 3 | 7 | +/+ | - |
ML0840 | hypothetical protein | 434 | - | 66 (MAV_2053) | - | - | - | 3 | 22 | +/+ | - |
ML0276 | hypothetical protein | 147 | - | 71 (MAV_4774) | 78 (BCG_0427) | 70 (MMAR_0687) | 78 (Rv0390) | 5 | 14 | +/+ | +/- |
ML2541 | acyl-CoA synthase (pseudogene) | 146 | 77 (MUL_0004) | 78 (MAV_0004) | 83 (BCG_0004) | 78 (MMAR_0004) | 77 (Rv0004) | 5 | 15 | +/- | - |
ML2203 | hypothetical protein | 373 | 76 (MUL_0420) | 76 (MAV_0750) | 77 (BCG_0863c) | 75 (MMAR_4878) | 77 (Rv0811c) | 6 | 17 | +/- | - |
ML2358 | probable acyl-CoA synthase | 583 | 77 (MUL_2020) | 56 (MAV_1328) | 77 (BCG_2952) | 77 (MMAR_1777) | 76 (Rv2930), | 3 | 15 | +/- | - |
ML2346 | hypothetical protein | 301 | - | - | - | - | - | 5 | 12 | +/- | - |
ML2380 | possible secreted protein | 153 | 65 (MUL_1413) | 66 (MAV_4695) | 66 (BCG_0494c) | 65 (MMAR_0777) | 66 (Rv0455c) | 3 | 15 | +/- | - |
ML2603 | possible lysophospholipase | 279 | 73 (MUL_1077) | 77 (MAV_4997) | 74 (BCG_0220) | 74 (MMAR_0427) | 74 (Rv0183) | 5 | 16 | +/- | - |
ML0022 | hypothetical protein | 488 | 71 (MUL_0024) | 66 (MAV_0024) | 72 (BCG_0050c) | 69 (MMAR_0022) | 72 (Rv0020) | 5 | 17 | +/- | - |