Skip to main content

Table 5 Sensitivity, Specificity, PPV and NPV of Current WHO TLC thresholds and Proposed new raised TLC thresholds to Identify Severely Immuno-suppressed Children

From: Utility of total lymphocyte count as a surrogate marker for CD4 counts in HIV-1 infected children in Kenya

Age group in months

Current WHO TLC threshold (cells/mm3)

Sensitivity

Specificity

PPVa

NPVb

No. of children

<12

4000

25

100

100

37

82

12-35

3000

23

98

93

58

129

36-59

2500

33

92

68

74

118

>59

2000

62

83

74

74

158

ALL

 

36c

93c

84c

61c

487

Age group in months

Proposed Optimal TLC

Sensitivity

Specificity

PPV

NPV

No. of Children

<12

7000

71

73

85

54

82

12-35

6000

65

62

61

65

129

36-59

4500

60

54

37

71

118

>59

3000

86

68

68

87

158

ALL

 

71

64

63

69

487

  1. aPPV = positive predictive value bNPV = negative predictive value cMean value for the four age groups