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Table 2 Comparison of malaria clinical signs and symptoms with blood smear results in patients admitted for severe malaria at Bombo hospital, Tanga, Tanzania

From: Prospective study on severe malaria among in-patients at Bombo regional hospital, Tanga, north-eastern Tanzania

  Clinical observation alone     
Signs & symptoms Initial total cases*+ Reassessed cases (n,%)**+ No. +ve (n,%) Odds ratio P-value 95% CI
Clinical manifestations* 494 369 (74.7) 227 (61.5) 1.63 0.008 1.136 - 2.350
Cerebral malaria** 273 129 (47.3) 89 (69.0) 1.34 0.26 0.807 - 2.208
Severe anaemia 494 72 (14.6) 61 (84.7) 4.85 0.001 2.509 - 9.578
Hyperpyrexia† 494 97 (19.6) 59 (60.8) 1.17 0.486 0.746 - 1.849
Hyperparasitaemia†† 494 285 (57.7) 4 (1.4)   0.085  
Convulsions 494 23 (4.7) 17 (73.9) 2.15 0.107 0.831 - 5.540
Jaundice 494 6 (1.2) 3 (50.0) 0.73 0.701 0.146 - 3.656
  1. *+Initial total cases are those admitted with diagnosis of severe malaria from OPD
  2. **+Reassessed cases are those confirmed to have severe malaria by investigators.
  3. *Clinical signs and symptoms used as inclusion criteria for severe malaria
  4. **According to the Blantyre coma score scale
  5. †Axillary temperature ≥ 39.5°C
  6. ††Parasite count ≥ 250,000/μL of blood