Skip to main content

Table 2 Results of phenotypic testing, sequencing, MTBDRsl and spoligotyping

From: Molecular detection of fluoroquinolone-resistance in multi-drug resistant tuberculosis in Cambodia suggests low association with XDR phenotypes

MDR strains

Number of strains

DST Phenotype

Molecular testing

Spoligotype

  

RMP

FQ

KM/AM

 
  

rpoB

gyrA

MTBDR sl

rrs (1401, 1402, 1484)

MTBDR sl

 

1

INH, RMP, SM

S531L

A90V

r

a1401g

r

EAI2-NTB

1

INH, RMP, SM

D516V

A90V mixed wt

r

wt

s

Beijing

1

INH, RMP, SM

S531L

D94A

r

nd

s

Beijing

2

INH, RMP, SM

S531L

D94A

r

wt

s

Beijing

1

INH, RMP, SM

H526Y

D94A

r

wt

s

Beijing

1

INH, RMP, SM

S531L

D94A

r

wt

s

Beijing

1

INH, RMP, SM

S531L

D94A

r

wt

s

Beijing

1

INH, RMP, SM

L533P

D94A mixed wt

r

wt

s

Beijing

1

INH, RMP, SM

D516V

D94G

r

wt

s

Beijing

1

INH, RMP, SM

H526D

D94G

r

wt

s

Beijing

1

INH, RMP, SM

S531L

D94G

r

wt

s

EAI1_SOM

1

INH, RMP, SM

S531L

D94G

r

wt

s

U

1

INH, RMP, SM

S531L

D94G mixed wt

r

wt

s

U

1

INH, RMP

S531L

wt

s

wt

s

Beijing

1

INH, RMP

S531L

wt

s

wt

s

Beijing

1

INH, RMP

S531L

wt

s

wt

s

Beijing

1

INH, RMP, SM

H526N L533P

wt

s

wt

s

Beijing

1

INH, RMP, SM

H526R

wt

s

wt

s

Beijing

1

INH, RMP, SM

R529Q mixed wt

wt

s

wt

s

Beijing

1

INH, RMP, SM

D516G S531L

wt

s

wt

s

Beijing

1

INH, RMP, SM

D516V

wt

s

wt

s

Beijing

1

INH, RMP, SM

D516V

wt

s

wt

s

Beijing

1

INH, RMP, SM

D516V

wt

s

wt

s

Beijing

1

INH, RMP, SM

D516V

wt

s

wt

s

Beijing

1

INH, RMP, SM

D516V

wt

s

wt

s

Beijing

1

INH, RMP, SM

D516V mixed wt

wt

s

wt

s

Beijing

1

INH, RMP, SM

D516V mixed wt; S531L

wt

s

wt

s

Beijing

1

INH, RMP, SM

insertion ttc 514; A532V

wt

s

nd

s

Beijing

1

INH, RMP, SM

S531L

wt

s

wt

s

Beijing

1

INH, RMP, SM

S531L

wt

s

wt

s

Beijing

1

INH, RMP, SM

S531L

wt

s

wt

s

Beijing

1

INH, RMP, SM

S531L

wt

s

wt

s

Beijing

1

INH, RMP, SM

S531L

wt

s

wt

s

Beijing

1

INH, RMP, SM

S531L

wt

s

wt

s

Beijing

1

INH, RMP, SM

S531L

wt

s

wt

s

Beijing

1

INH, RMP, SM

S531L

wt

s

wt

s

Beijing

2

INH, RMP, SM

S531L

wt

s

wt

s

Beijing

1

INH, RMP, SM

wt

wt

s

wt

s

Beijing

1

INH, RMP, SM

S512N T525T H526P L527Q

wt

s

wt

s

Beijing

1

INH, RMP, SM

H526D

wt

s

wt

s

Beijing

1

INH, RMP, SM

H526Y

wt

s

wt

s

Beijing

1

INH, RMP, SM

H526Y

wt

s

wt

s

Beijing

2

INH, RMP, SM

H526N L533P

wt

s

wt

s

Beijing

1

INH, RMP, SM

H526R

wt

s

wt

s

Beijing

1

INH, RMP, SM

H526R

wt

s

wt

s

Beijing

1

INH, RMP, SM

L533P

wt

s

wt

s

Beijing

1

INH, RMP, SM

D516V mixed wt; S531L

wt

s

wt

s

Beijing

1

INH, RMP, SM

insertion ttc 514

wt

s

wt

s

Beijing

1

INH, RMP, SM

insertion ttc 514

wt

s

wt

s

Beijing

2

INH, RMP, SM

S531L

wt

s

wt

s

Beijing

1

INH, RMP, SM

S531L

wt

s

wt

s

Beijing

1

INH, RMP, SM

S531L

wt

s

wt

s

Beijing

2

INH, RMP, SM

S531L

wt

s

wt

s

Beijing

1

INH, RMP, SM

S531L

wt

s

wt

s

Beijing

1

INH, RMP, SM

L524W T525P del 526

wt

s

wt

s

Beijing

1

INH, RMP, SM

wt

wt

s

wt

s

Beijing

1

INH, RMP, SM

S531L

wt

s

wt

s

Beijing-like

1

INH, RMP, SM

wt

wt

s

wt

s

Beijing-like

1

INH, RMP

del 518

wt

s

wt

s

EAI1_SOM

1

INH, RMP

S531L

wt

s

wt

s

EAI1_SOM

1

INH, RMP

wt

wt

s

nd

s

EAI1_SOM

1

INH, RMP, SM

S531L

wt

s

wt

s

EAI1_SOM

1

INH, RMP, SM

H526D

wt

s

wt

s

EAI1_SOM

1

INH, RMP, SM

S531L

wt

s

nd

s

EAI1_SOM-EAI2

1

INH, RMP, SM

S531L

wt

s

wt

s

EAI4_VNM

1

INH, RMP, SM

H526D

wt

s

wt

s

EAI5

2

INH, RMP, SM

D516Q Q517N del 518

wt

s

wt

s

EAI5

1

INH, RMP, SM

S531L

wt

s

nd

s

EAI5

1

INH, RMP

L533P

wt

s

wt

s

EAI5

1

INH, RMP

S531L

wt

s

wt

s

EAI5

1

INH, RMP

L533P

wt

s

wt

s

U

1

INH, RMP

D516V

wt

s

wt

s

U

1

INH, RMP, SM

D516V mixed wt

wt

s

wt

s

U

1

INH, RMP, SM

H526D

wt

s

wt

s

U

2

INH, RMP, SM

H526D

wt

s

wt

s

U

1

INH, RMP, SM

S531L

wt

s

wt

s

U

1

INH, RMP, SM

S531L

wt

s

wt

s

U

1

INH, RMP

H526D mixed wt

wt

s

wt

s

Unknown

1

INH, RMP

S531L

wt

s

wt

s

Unknown

1

INH, RMP

S531L

wt

s

wt

s

Unknown

1

INH, RMP

wt

wt

s

wt

s

Unknown

1

INH, RMP

wt

wt

s

wt

s

Unknown

1

INH, RMP, SM

H526Y

wt

s

wt

s

Unknown

1

INH, RMP, SM

H526D R529Q

wt

s

wt

s

Unknown

2

INH, RMP, SM

S531L

wt

s

wt

s

Unknown

1

INH, RMP, SM

S531L

wt

s

wt

s

Unknown

1

INH, RMP, SM

H526Y

wt

s

wt

s

Unknown

1

INH, RMP, SM

D516V

wt

s

wt

s

Unknown

1

INH, RMP, SM

D516V

wt

s

nd

s

Unknown

1

INH, RMP, SM

S531L

wt

s

wt

s

Unknown

1

INH, RMP, SM

S531L

wt

s

wt

s

Unknown

1

INH, RMP, SM

S531L

wt

s

wt

s

Unknown

1

INH, RMP, SM

D516G

wt

s

nd

s

ZERO

  1. INH isoniazid, RMP rifampicin, SM streptomycin
  2. AM amikacin, FQ fluoroquinolones, KM kanamycin
  3. wt wild type, s susceptible, r resistant, nd not determined