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Table 2 Results of phenotypic testing, sequencing, MTBDRsl and spoligotyping

From: Molecular detection of fluoroquinolone-resistance in multi-drug resistant tuberculosis in Cambodia suggests low association with XDR phenotypes

MDR strains
Number of strains DST Phenotype Molecular testing Spoligotype
   RMP FQ KM/AM  
   rpoB gyrA MTBDR sl rrs (1401, 1402, 1484) MTBDR sl  
1 INH, RMP, SM S531L A90V r a1401g r EAI2-NTB
1 INH, RMP, SM D516V A90V mixed wt r wt s Beijing
1 INH, RMP, SM S531L D94A r nd s Beijing
2 INH, RMP, SM S531L D94A r wt s Beijing
1 INH, RMP, SM H526Y D94A r wt s Beijing
1 INH, RMP, SM S531L D94A r wt s Beijing
1 INH, RMP, SM S531L D94A r wt s Beijing
1 INH, RMP, SM L533P D94A mixed wt r wt s Beijing
1 INH, RMP, SM D516V D94G r wt s Beijing
1 INH, RMP, SM H526D D94G r wt s Beijing
1 INH, RMP, SM S531L D94G r wt s EAI1_SOM
1 INH, RMP, SM S531L D94G r wt s U
1 INH, RMP, SM S531L D94G mixed wt r wt s U
1 INH, RMP S531L wt s wt s Beijing
1 INH, RMP S531L wt s wt s Beijing
1 INH, RMP S531L wt s wt s Beijing
1 INH, RMP, SM H526N L533P wt s wt s Beijing
1 INH, RMP, SM H526R wt s wt s Beijing
1 INH, RMP, SM R529Q mixed wt wt s wt s Beijing
1 INH, RMP, SM D516G S531L wt s wt s Beijing
1 INH, RMP, SM D516V wt s wt s Beijing
1 INH, RMP, SM D516V wt s wt s Beijing
1 INH, RMP, SM D516V wt s wt s Beijing
1 INH, RMP, SM D516V wt s wt s Beijing
1 INH, RMP, SM D516V wt s wt s Beijing
1 INH, RMP, SM D516V mixed wt wt s wt s Beijing
1 INH, RMP, SM D516V mixed wt; S531L wt s wt s Beijing
1 INH, RMP, SM insertion ttc 514; A532V wt s nd s Beijing
1 INH, RMP, SM S531L wt s wt s Beijing
1 INH, RMP, SM S531L wt s wt s Beijing
1 INH, RMP, SM S531L wt s wt s Beijing
1 INH, RMP, SM S531L wt s wt s Beijing
1 INH, RMP, SM S531L wt s wt s Beijing
1 INH, RMP, SM S531L wt s wt s Beijing
1 INH, RMP, SM S531L wt s wt s Beijing
1 INH, RMP, SM S531L wt s wt s Beijing
2 INH, RMP, SM S531L wt s wt s Beijing
1 INH, RMP, SM wt wt s wt s Beijing
1 INH, RMP, SM S512N T525T H526P L527Q wt s wt s Beijing
1 INH, RMP, SM H526D wt s wt s Beijing
1 INH, RMP, SM H526Y wt s wt s Beijing
1 INH, RMP, SM H526Y wt s wt s Beijing
2 INH, RMP, SM H526N L533P wt s wt s Beijing
1 INH, RMP, SM H526R wt s wt s Beijing
1 INH, RMP, SM H526R wt s wt s Beijing
1 INH, RMP, SM L533P wt s wt s Beijing
1 INH, RMP, SM D516V mixed wt; S531L wt s wt s Beijing
1 INH, RMP, SM insertion ttc 514 wt s wt s Beijing
1 INH, RMP, SM insertion ttc 514 wt s wt s Beijing
2 INH, RMP, SM S531L wt s wt s Beijing
1 INH, RMP, SM S531L wt s wt s Beijing
1 INH, RMP, SM S531L wt s wt s Beijing
2 INH, RMP, SM S531L wt s wt s Beijing
1 INH, RMP, SM S531L wt s wt s Beijing
1 INH, RMP, SM L524W T525P del 526 wt s wt s Beijing
1 INH, RMP, SM wt wt s wt s Beijing
1 INH, RMP, SM S531L wt s wt s Beijing-like
1 INH, RMP, SM wt wt s wt s Beijing-like
1 INH, RMP del 518 wt s wt s EAI1_SOM
1 INH, RMP S531L wt s wt s EAI1_SOM
1 INH, RMP wt wt s nd s EAI1_SOM
1 INH, RMP, SM S531L wt s wt s EAI1_SOM
1 INH, RMP, SM H526D wt s wt s EAI1_SOM
1 INH, RMP, SM S531L wt s nd s EAI1_SOM-EAI2
1 INH, RMP, SM S531L wt s wt s EAI4_VNM
1 INH, RMP, SM H526D wt s wt s EAI5
2 INH, RMP, SM D516Q Q517N del 518 wt s wt s EAI5
1 INH, RMP, SM S531L wt s nd s EAI5
1 INH, RMP L533P wt s wt s EAI5
1 INH, RMP S531L wt s wt s EAI5
1 INH, RMP L533P wt s wt s U
1 INH, RMP D516V wt s wt s U
1 INH, RMP, SM D516V mixed wt wt s wt s U
1 INH, RMP, SM H526D wt s wt s U
2 INH, RMP, SM H526D wt s wt s U
1 INH, RMP, SM S531L wt s wt s U
1 INH, RMP, SM S531L wt s wt s U
1 INH, RMP H526D mixed wt wt s wt s Unknown
1 INH, RMP S531L wt s wt s Unknown
1 INH, RMP S531L wt s wt s Unknown
1 INH, RMP wt wt s wt s Unknown
1 INH, RMP wt wt s wt s Unknown
1 INH, RMP, SM H526Y wt s wt s Unknown
1 INH, RMP, SM H526D R529Q wt s wt s Unknown
2 INH, RMP, SM S531L wt s wt s Unknown
1 INH, RMP, SM S531L wt s wt s Unknown
1 INH, RMP, SM H526Y wt s wt s Unknown
1 INH, RMP, SM D516V wt s wt s Unknown
1 INH, RMP, SM D516V wt s nd s Unknown
1 INH, RMP, SM S531L wt s wt s Unknown
1 INH, RMP, SM S531L wt s wt s Unknown
1 INH, RMP, SM S531L wt s wt s Unknown
1 INH, RMP, SM D516G wt s nd s ZERO
  1. INH isoniazid, RMP rifampicin, SM streptomycin
  2. AM amikacin, FQ fluoroquinolones, KM kanamycin
  3. wt wild type, s susceptible, r resistant, nd not determined