Invasive fungal sinusitis in patients with hematological malignancy: 15 years experience in a single university hospital in Taiwan

Table 4 Univariate analysis outcome in patients with hematological disorders.

	IFS (n = 46)		P	Odds Ratio	95%CI
	Alive (n = 27)	Dead (n = 19)
Age			0.51
≥ 60 years	6	6
< 60 years	21	13
Gender			0.55
Male	17	10
Female	10	9
Hematological diseases			0.04	5.84	1.02-30.56
AML	16	17
Non-AML*	11	2
Disease status			0.05	4.27	1.003-18.15
Fresh diagnosis/remission	12	3
Relapse/refractory	15	16
Underlying diabetes mellitus			> 0.99
Yes	2	2
No	25	17
Chemotherapy intensity			0.25
Supportive care	5	6
Low dose chemotherapy	3	5
Standard dose chemotherapy	16	6
High dose chemotherapy	3	2
Absolute neutrophil count			0.68
< 500 mm³ < 10 days	5	2
< 500 mm³≥10 days	22	17
Allogeneic transplantation			0.68
Yes	3	3
No	24	16
FESS debridement			0.10	0.27	0.064-1.17
Yes	11	3
No	16	16
Fungus type			0.21
Aspergillosis	12	5
Mucormycosis	2	2
Others**	2	2
Unknown	10	12
Invasive image pattern***			0.34
Yes	7	8
No	20	11
Pre-emptive antifungal agent			0.29
Amphotericin B/ambisome	15	13
Caspofungin	0	0
Voriconazole	2	0
Amphotericin B and caspofungin	1	3
Amphotericin B and voriconazole	7	4

Abbreviation: AML, acute myeloid leukemia; FESS: functional endoscopic sinus surgery.
*Non -AML: including acute lymphoblastic leukemia 6 cases, severe aplastic anemia/myelodysplastic syndrome, 2 cases, other: CLL, 2 cases, CML 1 case
**. Others: Phaeohyphomycosis, Fusarium mycosis, Penicillium mycosis, and unidentified mycosis
***. Invasive image pattern indicates brain abscess, invasion of tissue.

ISSN: 1471-2334