Skip to main content

Advertisement

Table 4 Univariate analysis outcome in patients with hematological disorders.

From: Invasive fungal sinusitis in patients with hematological malignancy: 15 years experience in a single university hospital in Taiwan

  IFS (n = 46) P Odds Ratio 95%CI
  Alive (n = 27) Dead (n = 19)    
Age    0.51   
   ≥ 60 years 6 6    
   < 60 years 21 13    
Gender    0.55   
   Male 17 10    
   Female 10 9    
Hematological diseases    0.04 5.84 1.02-30.56
   AML 16 17    
   Non-AML* 11 2    
Disease status    0.05 4.27 1.003-18.15
   Fresh diagnosis/remission 12 3    
   Relapse/refractory 15 16    
Underlying diabetes mellitus    > 0.99   
   Yes 2 2    
   No 25 17    
Chemotherapy intensity    0.25   
   Supportive care 5 6    
   Low dose chemotherapy 3 5    
   Standard dose chemotherapy 16 6    
   High dose chemotherapy 3 2    
Absolute neutrophil count    0.68   
   < 500 mm3 < 10 days 5 2    
   < 500 mm3≥10 days 22 17    
Allogeneic transplantation    0.68   
   Yes 3 3    
   No 24 16    
FESS debridement    0.10 0.27 0.064-1.17
   Yes 11 3    
   No 16 16    
Fungus type    0.21   
   Aspergillosis 12 5    
   Mucormycosis 2 2    
   Others** 2 2    
   Unknown 10 12    
Invasive image pattern***    0.34   
   Yes 7 8    
   No 20 11    
Pre-emptive antifungal agent    0.29   
   Amphotericin B/ambisome 15 13    
   Caspofungin 0 0    
   Voriconazole 2 0    
   Amphotericin B and caspofungin 1 3    
   Amphotericin B and voriconazole 7 4    
  1. Abbreviation: AML, acute myeloid leukemia; FESS: functional endoscopic sinus surgery.
  2. *Non -AML: including acute lymphoblastic leukemia 6 cases, severe aplastic anemia/myelodysplastic syndrome, 2 cases, other: CLL, 2 cases, CML 1 case
  3. **. Others: Phaeohyphomycosis, Fusarium mycosis, Penicillium mycosis, and unidentified mycosis
  4. ***. Invasive image pattern indicates brain abscess, invasion of tissue.