Toxicity | No events | Person Time (years) | Rate/100 pys* (95% CI)‡ | Crude HR§ (95% CI)‡ | Adjusted†HR (95% CI)‡ |
---|---|---|---|---|---|
Peripheral Neuropathy Other d4T-based | 61 1454 | 775.9 12055.5 | 7.9 (6.0-10.1) 12.1 (7.0-19.5) | 1.0 1.53 (1.19-1.98) | 1.0 2.02 (1.35-3.03) |
Symptomatic hyperlactataemia Other d4T-based | 12 487 | 852.3 13690.9 | 1.4 (0.7-2.5) 3.6 (1.2-7.5) | 1.0 2.70 (1.52-4.79) | 1.0 2.81 (1.26-6.31) |
Lactic acidosis Other d4T-based | 7 214 | 848.3 13805.9 | 0.8 (0.3-1.7) 1.6 (0.4-5.2) | 1.0 2.09 (0.99-4.44) | 1.0 2.55 (0.81-8.00) |
Pancreatitis Other d4T-based | 1 14 | 858.9 14126.2 | 0.1 (0.003-0.6) 0.1 (0.02-2.6) | 1.0 0.95 (0.13-7.21) | 1.0 0.40 (0.05-3.16) |
Lipoatrophy Other d4T-based | 25 616 | 834.0 13534.3 | 3.0 (1.9-4.4) 4.6 (2.1-9.6) | 1.0 1.67 (1.12-2.50) | 1.0 1.60 (0.92-2.77) |
Hypertension Other d4T-based | 17 167 | 845.0 13929.0 | 2.0 (1.2-3.2) 1.2 (0.2-4.0) | 1.0 0.66 (0.40-1.08) | 1.0 0.83 (0.39-1.78) |
Diabetes Mellitus Other d4T-based | 1 28 | 859.0 14122.7 | 0.1 (0.003-0.6) 0.2 (0.02-2.6) | 1.0 1.90 (0.26-14.04) | 1.0 2.07 (0.28-15.21) |
Dyslipidaemia Other d4T-based | 9 109 | 856.5 14097.2 | 1.1 (0.4-2.0) 0.8 (0.2-4.0) | 1.0 0.82 (0.41-1.61) | 1.0 0.61 (0.27-1.40) |