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Table 3 Significant differences in the clinical characteristics of patients with NNHCA-IE compared to community-acquired IE, as determined by multivariate analysis

From: Non-nosocomial healthcare-associated infective endocarditis in Taiwan: an underrecognized disease with poor outcome

  NNHCA-IE Community- Univariate Multivariate 1
  n = 30 acquired IE
n = 148
OR (95%CI) pvalue OR (95%CI) pvalue
Age 65 years, n (%) 19 (63.3) 27 (18.2) 7.7 (3.3-18.1) < 0.001   
Women, n (%) 13 (43.3) 28 (18.9) 3.3 (1.4-7.5) 0.004   
Charlson comorbidity index 2 n (%) 27 (90.0) 27 (18.2) 40.3 (11.4-142.7) < 0.001 27.5 (6.9-110.3) < 0.001
Diabetes mellitus, n (%) 17 (56.7) 25 (16.9) 6.4 (2.8-14.9) < 0.001   
Hypertension, n (%) 20 (66.7) 26 (17.6) 9.4 (3.9-22.4) < 0.001 7.5 (2.2-25.1) 0.001
Symptoms duration 7 days n (%) 25 (83.3) 95 (64.2) 2.8 (1.0-7.7) 0.041   
Staphylococci infection, n (%) 23 (76.7) 75 (50.7) 3.2 (1.3-7.9) 0.009   
MRSA infection, n (%) 13 (43.3) 14 (9.5) 7.3 (3.0-18.1) < 0.001 12.2 (2.9-51.5) 0.001
Streptococci infection, n (%) 4 (13.3) 51 (34.5) 0.3 (0.1-0.9) 0.022   
  1. 1 Adjusted for age and sex
  2. NNHCA-IE, non-nosocomial healthcare-associated infective endocarditis; OR, odds ratio; CI, confidence interval; MRSA, methicillin-resistant Staphylococcus aureus