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Table 5 Univariate analysis of prognostic factors for sequelae in childhood BM

From: Prognostic factors related to sequelae in childhood bacterial meningitis: Data from a Greek meningitis registry

   All BM cases (n = 2382) Confirmed cases (n = 1297)
Prognostic Factors Sequelae/Prognostic factor* (%) RR (95% CI) P-value Sequelae/Prognostic factor* (%) RR (95% CI) P-value
Etiology
   N. meningitidis Yes 15/1091 (1.4) 0.26 (0.15-0.46) < 0.001 15/763 (2.0) 0.22 (0.12-0.39) < 0.001
  No 58/1116 (5.2)     40/445 (9.0)    
   S. pneumoniae Yes 20/161 (12.4) 4.80 (2.94-7.82) < 0.001 20/161 (12.4) 3.72 (2.20-6.27) < 0.001
  No 53/2046 (2.6)     35/1047 (3.3)    
   H. influenzae Yes 11/240 (4.6) 1.45 (0.78-2.72) 0.163 11/240 (4.6) 1.01 (0.53-1.92) 0.980
  No 62/1967 (3.2)     44/968 (4.5)    
   Other bacteria Yes 9/44 (20.5) 6.91 (3.68-12.99) < 0.001 9/44 (20.5) 5.18 (2.71-9.89) < 0.001
  No 64/2163 (3.0)     46/1164 (4.0)    
   Unknown Yes 18/671 (2.7) 0.75 (0.44-1.27) 0.170 - - - - -
  No 55/1536 (3.6)     - -    
Various Characteristics
   Male sex Yes 45/1296 (3.5) 1.12 (0.71-1.79) 0.356 33/690 (4.8) 1.12 (0.66-1.90) 0.669
  No 28/907 (3.1)     22/516 (4.3)    
   Duration of symptoms < 24 h Yes 5/423 (1.2) 0.32 (0.13-0.80) 0.004 3/240 (1.3) 0.24 (0.07-0.75) 0.007
  No 56/1524 (3.7)     44/828 (5.3)    
   Age < 2 y Yes 50/1038 (4.8) 2.43 (1.49-3.99) < 0.001 39/624 (6.3) 2.15 (1.22-3.81) 0.007
  No 22/1112 (2.0)     16/551 (2.9)    
   Period C Yes 11/384 (2.9) 0.84 (0.45-1.58) 0.364 11/247 (4.5) 0.97 (0.51-1.86) 0.933
  No 62/1823 (3.4)     44/961 (4.6)    
  1. * Prognostic factor population varies due to missing values
  2. Missing values ranged from 7.3% to 18.3%