|  | All BM cases (n = 2382) | Confirmed cases (n = 1297) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Prognostic factors | Sequelae/Prognostic factor* (%) | RR | (95% CI) | P-value | Sequelae/Prognostic factor* (%) | RR | (95% CI) | P-value | |||
CSF fluid analysis at presentation | |||||||||||
   Positive CSF culture | Yes | 41/904 | (4.5) | 2.18 | (1.30-3.66) | 0.002 | 41/901 | (4.5) | 1.41 | (0.64-3.10) | 0.387 |
 | No | 21/1009 | (2.1) |  |  |  | 7/217 | (3.2) |  |  |  |
   Positive Gram stain | Yes | 41/732 | (5.6) | 2.86 | (1.72-4.76) | < 0.001 | 40/725 | (5.5) | 2.05 | (1.01-4.18) | 0.041 |
 | No | 22/1123 | (2.0) |  |  |  | 9/335 | (2.7) |  |  |  |
   CSF WBC ≤ 100/μL | Yes | 8/341 | (2.3) | 0.67 | (0.32-1.37) | 0.172 | 5/175 | (2.9) | 0.59 | (0.24-1.45) | 0.237 |
 | No | 65/1843 | (3.5) |  |  |  | 50/1024 | (4.9) |  |  |  |
   CSF WBC ≤ 1000/μL | Yes | 24/945 | (2.5) | 0.64 | (0.40-1.04) | 0.043 | 16/383 | (4.2) | 0.87 | (0.49-1.54) | 0.642 |
 | No | 49/1239 | (4.0) |  |  |  | 39/816 | (4.8) |  |  |  |
   CSF Glu < 40 mg/dL | Yes | 57/949 | (6.0) | 5.53 | (2.98-0.24) | < 0.001 | 46/665 | (6.9) | 4.81 | (2.19-10.57) | < 0.001 |
 | No | 12/1104 | (1.1) |  |  |  | 7/487 | (1.4) |  |  |  |
   CSF Protein > 100 mg/dL | Yes | 52/987 | (5.3) | 3.34 | (1.95-5.74) | < 0.001 | 43/646 | (6.7) | 3.31 | (1.68-6.53) | < 0.001 |
 | No | 17/1078 | (1.6) |  |  |  | 10/498 | (2.0) |  |  |  |
   ≥ 65% neutrophils in CSF | Yes | 57/1534 | (3.7) | 1.75 | (0.76-4.01) | 0.119 | 44/911 | (4.8) | 1.43 | (0.45-4.52) | 0.383 |
 | No | 6/282 | (2.1) |  |  |  | 3/89 | (3.4) |  |  |  |
Peripheral blood analysis at presentation | |||||||||||
   Positive blood culture | Yes | 18/256 | (7.0) | 3.11 | (1.76-5.52) | < 0.001 | 18/251 | (7.2) | 2.72 | (1.41-5.25) | 0.002 |
 | No | 29/1284 | (2.3) |  |  |  | 16/607 | (2.6) |  |  |  |
   Peripheral WBC < 5000/μL | Yes | 3/104 | (2.9) | 0.85 | (0.27-2.66) | 0.533 | 3/83 | (3.6) | 0.77 | (0.24-2.41) | 0.455 |
 | No | 68/2009 | (3.4) |  |  |  | 51/1084 | (4.7) |  |  |  |
   Peripheral WBC ≥ 15000/μL | Yes | 26/921 | (2.8) | 0.75 | (0.47-1.20) | 0.139 | 18/505 | (3.6) | 0.66 | (0.38-1.14) | 0.131 |
 | No | 45/1192 | (3.8) |  |  |  | 36/662 | (5.4) |  |  |  |
   Absolute blood neutrophil count < 1000/μL | Yes | 1/13 | (7.7) | 2.38 | (0.36-5.92) | 0.350 | 1/11 | (9.1) | 2.04 | (0.31-13.49) | 0.399 |
 | No | 64/1984 | (3.2) |  |  |  | 49/1100 | (4.5) |  |  |  |