Skip to main content

Table 4 Univariate analysis of CSF and peripheral blood as prognostic factors for sequelae in childhood bacterial meningitis

From: Prognostic factors related to sequelae in childhood bacterial meningitis: Data from a Greek meningitis registry

  

All BM cases (n = 2382)

Confirmed cases (n = 1297)

Prognostic factors

Sequelae/Prognostic factor* (%)

RR

(95% CI)

P-value

Sequelae/Prognostic factor* (%)

RR

(95% CI)

P-value

CSF fluid analysis at presentation

   Positive CSF culture

Yes

41/904

(4.5)

2.18

(1.30-3.66)

0.002

41/901

(4.5)

1.41

(0.64-3.10)

0.387

 

No

21/1009

(2.1)

   

7/217

(3.2)

   

   Positive Gram stain

Yes

41/732

(5.6)

2.86

(1.72-4.76)

< 0.001

40/725

(5.5)

2.05

(1.01-4.18)

0.041

 

No

22/1123

(2.0)

   

9/335

(2.7)

   

   CSF WBC ≤ 100/μL

Yes

8/341

(2.3)

0.67

(0.32-1.37)

0.172

5/175

(2.9)

0.59

(0.24-1.45)

0.237

 

No

65/1843

(3.5)

   

50/1024

(4.9)

   

   CSF WBC ≤ 1000/μL

Yes

24/945

(2.5)

0.64

(0.40-1.04)

0.043

16/383

(4.2)

0.87

(0.49-1.54)

0.642

 

No

49/1239

(4.0)

   

39/816

(4.8)

   

   CSF Glu < 40 mg/dL

Yes

57/949

(6.0)

5.53

(2.98-0.24)

< 0.001

46/665

(6.9)

4.81

(2.19-10.57)

< 0.001

 

No

12/1104

(1.1)

   

7/487

(1.4)

   

   CSF Protein > 100 mg/dL

Yes

52/987

(5.3)

3.34

(1.95-5.74)

< 0.001

43/646

(6.7)

3.31

(1.68-6.53)

< 0.001

 

No

17/1078

(1.6)

   

10/498

(2.0)

   

   ≥ 65% neutrophils in CSF

Yes

57/1534

(3.7)

1.75

(0.76-4.01)

0.119

44/911

(4.8)

1.43

(0.45-4.52)

0.383

 

No

6/282

(2.1)

   

3/89

(3.4)

   

Peripheral blood analysis at presentation

   Positive blood culture

Yes

18/256

(7.0)

3.11

(1.76-5.52)

< 0.001

18/251

(7.2)

2.72

(1.41-5.25)

0.002

 

No

29/1284

(2.3)

   

16/607

(2.6)

   

   Peripheral WBC < 5000/μL

Yes

3/104

(2.9)

0.85

(0.27-2.66)

0.533

3/83

(3.6)

0.77

(0.24-2.41)

0.455

 

No

68/2009

(3.4)

   

51/1084

(4.7)

   

   Peripheral WBC ≥ 15000/μL

Yes

26/921

(2.8)

0.75

(0.47-1.20)

0.139

18/505

(3.6)

0.66

(0.38-1.14)

0.131

 

No

45/1192

(3.8)

   

36/662

(5.4)

   

   Absolute blood neutrophil count < 1000/μL

Yes

1/13

(7.7)

2.38

(0.36-5.92)

0.350

1/11

(9.1)

2.04

(0.31-13.49)

0.399

 

No

64/1984

(3.2)

   

49/1100

(4.5)

   
  1. * Study population varies due to missing values
  2. Missing values ranged from 8.3% to 35.3%