| | |
All BM cases (n = 2382)
|
Confirmed cases (n = 1297)
|
|---|
|
Prognostic factors
|
Sequelae/Prognostic factor* (%)
|
RR
|
(95% CI)
|
P-value
|
Sequelae/Prognostic factor* (%)
|
RR
|
(95% CI)
|
P-value
|
|---|
|
CSF fluid analysis at presentation
|
|
Positive CSF culture
|
Yes
|
41/904
|
(4.5)
|
2.18
|
(1.30-3.66)
|
0.002
|
41/901
|
(4.5)
|
1.41
|
(0.64-3.10)
|
0.387
|
| |
No
|
21/1009
|
(2.1)
| | | |
7/217
|
(3.2)
| | | |
|
Positive Gram stain
|
Yes
|
41/732
|
(5.6)
|
2.86
|
(1.72-4.76)
|
< 0.001
|
40/725
|
(5.5)
|
2.05
|
(1.01-4.18)
|
0.041
|
| |
No
|
22/1123
|
(2.0)
| | | |
9/335
|
(2.7)
| | | |
|
CSF WBC ≤ 100/μL
|
Yes
|
8/341
|
(2.3)
|
0.67
|
(0.32-1.37)
|
0.172
|
5/175
|
(2.9)
|
0.59
|
(0.24-1.45)
|
0.237
|
| |
No
|
65/1843
|
(3.5)
| | | |
50/1024
|
(4.9)
| | | |
|
CSF WBC ≤ 1000/μL
|
Yes
|
24/945
|
(2.5)
|
0.64
|
(0.40-1.04)
|
0.043
|
16/383
|
(4.2)
|
0.87
|
(0.49-1.54)
|
0.642
|
| |
No
|
49/1239
|
(4.0)
| | | |
39/816
|
(4.8)
| | | |
|
CSF Glu < 40 mg/dL
|
Yes
|
57/949
|
(6.0)
|
5.53
|
(2.98-0.24)
|
< 0.001
|
46/665
|
(6.9)
|
4.81
|
(2.19-10.57)
|
< 0.001
|
| |
No
|
12/1104
|
(1.1)
| | | |
7/487
|
(1.4)
| | | |
|
CSF Protein > 100 mg/dL
|
Yes
|
52/987
|
(5.3)
|
3.34
|
(1.95-5.74)
|
< 0.001
|
43/646
|
(6.7)
|
3.31
|
(1.68-6.53)
|
< 0.001
|
| |
No
|
17/1078
|
(1.6)
| | | |
10/498
|
(2.0)
| | | |
|
≥ 65% neutrophils in CSF
|
Yes
|
57/1534
|
(3.7)
|
1.75
|
(0.76-4.01)
|
0.119
|
44/911
|
(4.8)
|
1.43
|
(0.45-4.52)
|
0.383
|
| |
No
|
6/282
|
(2.1)
| | | |
3/89
|
(3.4)
| | | |
|
Peripheral blood analysis at presentation
|
|
Positive blood culture
|
Yes
|
18/256
|
(7.0)
|
3.11
|
(1.76-5.52)
|
< 0.001
|
18/251
|
(7.2)
|
2.72
|
(1.41-5.25)
|
0.002
|
| |
No
|
29/1284
|
(2.3)
| | | |
16/607
|
(2.6)
| | | |
|
Peripheral WBC < 5000/μL
|
Yes
|
3/104
|
(2.9)
|
0.85
|
(0.27-2.66)
|
0.533
|
3/83
|
(3.6)
|
0.77
|
(0.24-2.41)
|
0.455
|
| |
No
|
68/2009
|
(3.4)
| | | |
51/1084
|
(4.7)
| | | |
|
Peripheral WBC ≥ 15000/μL
|
Yes
|
26/921
|
(2.8)
|
0.75
|
(0.47-1.20)
|
0.139
|
18/505
|
(3.6)
|
0.66
|
(0.38-1.14)
|
0.131
|
| |
No
|
45/1192
|
(3.8)
| | | |
36/662
|
(5.4)
| | | |
|
Absolute blood neutrophil count < 1000/μL
|
Yes
|
1/13
|
(7.7)
|
2.38
|
(0.36-5.92)
|
0.350
|
1/11
|
(9.1)
|
2.04
|
(0.31-13.49)
|
0.399
|
| |
No
|
64/1984
|
(3.2)
| | | |
49/1100
|
(4.5)
| | | |
- * Study population varies due to missing values
- Missing values ranged from 8.3% to 35.3%
