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Table 3 Variations of clinical manifestations according to age

From: Prognostic factors related to sequelae in childhood bacterial meningitis: Data from a Greek meningitis registry

 

N/Total (%)

 

Clinical Features

Age < 1 y

(n = 786)

Age 1-4 y

(n = 932)

Age 5-9 y

(n = 480)

Age > = 10 y

(n = 208)

P- value

All cases

         

   Fever

383/408

(93.9)

421/459

(91.7)

225/236

(95.3)

101/109

(92.7)

0.303

   Shock

66/541

(12.2)

84/646

(13.0)

35/317

(11.0)

18/140

(12.9)

0.849

   Coma

29/525

(5.5)

58/639

(9.1)

33/317

(10.4)

32/145

(22.1)

< 0.001

   Bulging Fontanellea

371/637

(58.2)

37/235

(15.7)

-

-

-

-

< 0.001

   Gruntinga

372/646

(57.6)

91/260

(35.0)

-

-

-

-

< 0.001

   Poor feeding

330/603

(54.7)

103/585

(17.6)

0/257

(0.0)

4/121

(3.3)

< 0.001

   Seizures

155/600

(25.8)

134/678

(19.8)

24/316

(7.6)

14/137

(10.2)

< 0.001

   Headacheb

-

-

304/447

(68.0)

369/424

(87.0)

167/189

(88.4)

< 0.001

   Meningeal signsc

-

-

655/811

(80.8)

360/426

(84.5)

151/182

(83.0)

0.252

   Haemorrhagic rash

225/786

(28.6)

452/930

(48.6)

190/479

(39.7)

76/207

(36.7)

< 0.001

   Vomiting

269/622

(43.2)

477/792

(60.2)

289/424

(68.2)

123/179

(68.7)

< 0.001

Confirmed cases

        

   Fever

218/231

(94.4)

270/286

(94.4)

102/108

(94.4)

44/46

(95.7)

0.988

   Shock

40/312

(12.8)

48/397

(12.1)

20/144

(13.9)

6/56

(10.7)

0.918

   Coma

18/301

(6.0)

37/394

(9.4)

24/148

(16.2)

14/57

(24.6)

< 0.001

   Bulging Fontanellea

242/359

(67.4)

23/159

(14.5)

-

-

-

-

< 0.001

   Gruntinga

243/369

(65.9)

66/185

(35.7)

-

-

-

-

< 0.001

   Poor feeding

205/339

(60.5)

77/361

(21.3)

0/117

(0.0)

3/46

(6.5)

< 0.001

   Seizures

93/343

(27.4)

86/418

(20.6)

11/142

(7.7)

7/54

(13.0)

< 0.001

   Headacheb

-

-

174/250

(69.6)

157/183

(85.8)

66/75

(88.0)

< 0.001

   Meningeal signsc

-

-

414/501

(82.6)

148/183

(80.9)

55/70

(78.6)

0.660

   Haemorrhagic rash

119/440

(27.0)

274/570

(48.1)

102/204

(50.0)

39/80

(48.8)

< 0.001

   Vomiting

167/357

(46.8)

310/490

(63.3)

128/184

(69.6)

53/72

(73.6)

< 0.001

  1. a Study population excludes children ≥ 2 years old
  2. b Study population excludes children < 2 years old
  3. c Study population excludes children < 1 years old
  4. There were 71 missing values in Age
  5. Missing values ranged from 0% to 37.2%