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Table 3 Variations of clinical manifestations according to age

From: Prognostic factors related to sequelae in childhood bacterial meningitis: Data from a Greek meningitis registry

  N/Total (%)  
Clinical Features Age < 1 y
(n = 786)
Age 1-4 y
(n = 932)
Age 5-9 y
(n = 480)
Age > = 10 y
(n = 208)
P- value
All cases          
   Fever 383/408 (93.9) 421/459 (91.7) 225/236 (95.3) 101/109 (92.7) 0.303
   Shock 66/541 (12.2) 84/646 (13.0) 35/317 (11.0) 18/140 (12.9) 0.849
   Coma 29/525 (5.5) 58/639 (9.1) 33/317 (10.4) 32/145 (22.1) < 0.001
   Bulging Fontanellea 371/637 (58.2) 37/235 (15.7) - - - - < 0.001
   Gruntinga 372/646 (57.6) 91/260 (35.0) - - - - < 0.001
   Poor feeding 330/603 (54.7) 103/585 (17.6) 0/257 (0.0) 4/121 (3.3) < 0.001
   Seizures 155/600 (25.8) 134/678 (19.8) 24/316 (7.6) 14/137 (10.2) < 0.001
   Headacheb - - 304/447 (68.0) 369/424 (87.0) 167/189 (88.4) < 0.001
   Meningeal signsc - - 655/811 (80.8) 360/426 (84.5) 151/182 (83.0) 0.252
   Haemorrhagic rash 225/786 (28.6) 452/930 (48.6) 190/479 (39.7) 76/207 (36.7) < 0.001
   Vomiting 269/622 (43.2) 477/792 (60.2) 289/424 (68.2) 123/179 (68.7) < 0.001
Confirmed cases         
   Fever 218/231 (94.4) 270/286 (94.4) 102/108 (94.4) 44/46 (95.7) 0.988
   Shock 40/312 (12.8) 48/397 (12.1) 20/144 (13.9) 6/56 (10.7) 0.918
   Coma 18/301 (6.0) 37/394 (9.4) 24/148 (16.2) 14/57 (24.6) < 0.001
   Bulging Fontanellea 242/359 (67.4) 23/159 (14.5) - - - - < 0.001
   Gruntinga 243/369 (65.9) 66/185 (35.7) - - - - < 0.001
   Poor feeding 205/339 (60.5) 77/361 (21.3) 0/117 (0.0) 3/46 (6.5) < 0.001
   Seizures 93/343 (27.4) 86/418 (20.6) 11/142 (7.7) 7/54 (13.0) < 0.001
   Headacheb - - 174/250 (69.6) 157/183 (85.8) 66/75 (88.0) < 0.001
   Meningeal signsc - - 414/501 (82.6) 148/183 (80.9) 55/70 (78.6) 0.660
   Haemorrhagic rash 119/440 (27.0) 274/570 (48.1) 102/204 (50.0) 39/80 (48.8) < 0.001
   Vomiting 167/357 (46.8) 310/490 (63.3) 128/184 (69.6) 53/72 (73.6) < 0.001
  1. a Study population excludes children ≥ 2 years old
  2. b Study population excludes children < 2 years old
  3. c Study population excludes children < 1 years old
  4. There were 71 missing values in Age
  5. Missing values ranged from 0% to 37.2%