Characteristic | Number of events/person-years | Unadjusted HRa(95% CI) | Adjusted HRb(95% CI) | P-value |
---|---|---|---|---|
Cervical HPV DNA at baseline | ||||
HPV-6 positive, yes vs. no | ||||
Effect in 1st year of follow-up | 4/17 | 8.67 (1.86-40.40) | 9.09 (1.75-47.29) | 0.009 |
Effect after 1st year of follow-up | 1/12 | 0.12 (0.03-0.54) | 0.11 (0.02-0.57) | 0.009 |
HPV-11 positive, yes vs. no | 1/21 | 0.74 (0.07-7.58) | 1.17 (0.11-12.37) | 0.89 |
HPV-52 positive, yes vs. no | 9/50 | 3.73 (1.28-10.83) | 3.81 (0.90-16.23) | 0.07 |
Other HPV types, negative for types 6, 11,52 | 19/226 | 1.48 (0.64-3.45) | 2.64 (0.62-11.33) | 0.19 |
Cervical cytology at baseline (N = 296) | ||||
Normal | 9/369 | 1.0 | 1.0 | |
ASCUS/LSIL/HSIL | 23/134 | 7.38 (3.10-17.56) | 3.05 (1.17-7.92) | 0.02 |
HIV status, nadir CD4+ count | ||||
HIV seronegative | 4/289 | 1.0 | ||
HIV-1+, CD4 >200cells/μL | 11/119 | 3.22 (0.71-14.59) | 0.13 | |
HIV-1+, CD4 ≤200 cells/μL | 18/79 | 10.94 (2.60-46.12) | 0.001 |