Table 1 Characteristics of 226 Patients Receiving Fluoroquinolone (FQ) Antibiotics
From: Unnecessary use of fluoroquinolone antibiotics in hospitalized patients
Characteristic | Unnecessary (n = 70) | Necessary (n = 157) | P Value |
|---|---|---|---|
Age in years-median (IQR) | 65 (49, 80) | 59 (45, 72) | 0.045 |
Males | 30 (43) | 70 (45) | 0.81 |
Hospitalized in previous 12 months | 48 (69) | 101 (64) | 0.58 |
Antibiotics in previous 3 months | 29 (41) | 83 (53) | 0.11 |
   FQ antibiotics in previous 3 months | 11 (16) | 33 (21) | 0.35 |
Long-term care resident | 20 (29) | 36 (23) | 0.38 |
Comorbidities | Â | Â | Â |
   Diabetes | 23 (33) | 53 (34) | 0.89 |
   Cancer | 9 (13) | 30 (19) | 0.25 |
   Chronic neurological condition | 17 (24) | 28 (18) | 0.26 |
   Dementia | 12 (17) | 16 (10) | 0.14 |
Service First Prescribing FQs | Â | Â | Â |
   Emergency Department | 22 (31) | 55 (35) | 0.60 |
   Medicine | 25 (36) | 68 (43) | 0.28 |
   Surgery | 6 (9) | 21 (13) | 0.38 |
   Family Practice | 8 (11) | 6 (4) | 0.04 |
   Rehabilitation Medicine | 9 (13) | 3 (2) | 0.002 |
   Obstetrics/Gynecology | 0 (0) | 4 (3) | 0.31 |
Indication | Â | Â | Â |
   Treatment | 68 (97) | 150 (96) | 0.73 |
   Prophylaxis | 2 (3) | 7 (4) |  |
Regimen | Â | Â | Â |
   FQ as monotherapy | 46 (66) | 51 (32) | < 0.001 |
   FQ in combination with other antimicrobials | 24 (34) | 106 (68) |  |
Syndrome | Â | Â | Â |
   Urinary | 36 (51) | 28 (18) | < 0.001 |
   Pulmonary | 2 (3) | 50 (32) | < 0.001 |
   Upper respiratory tract | 4 (6) | 9 (6) | 1.000 |
   Bacteremia | 3 (4) | 7 (4) | 1.000 |
   Fever or sepsis syndrome | 3 (4) | 11 (7) | 0.56 |
   Diarrhea | 2 (3) | 3 (2) | 0.65 |
   Intra-abdominal | 2 (3) | 20 (13) | 0.03 |
   Skin and soft tissue | 4 (6) | 7 (5) | 0.74 |
   Non-infectious condition | 11 (16) | 18 (11) | 0.39 |
   Other | 3 (4) | 4 (3) | 0.68 |