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Figure 2 | BMC Infectious Diseases

Figure 2

From: Impact of early life exposures to geohelminth infections on the development of vaccine immunity, allergic sensitization, and allergic inflammatory diseases in children living in tropical Ecuador: the ECUAVIDA birth cohort study

Figure 2

Conceptual model for effects of maternal and infant geohelminth infections on vaccine immune responses measured at 7 months, 2 years or 5 years. Maternal infections would be expected to mediate effects on vaccine responses at 7 months and 2 years, although infant infections, generally acquired during the second year of life, may contribute to effects at 2 years. The suppressive effects of infant infections would be expected to be most important at 5 years. Potential immunological mechanisms that may mediate the suppressive effects of geohelminth exposures are shown in dashed boxes.

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