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Table 4 Predictive factors of first-line antibiotic treatment failure.

From: Bacterial infection profiles in lung cancer patients with febrile neutropenia

  Failure n = 24
n (%)
Success n = 63
n (%)
p value
Mean age (years) 69.2 62.33 <0.001
Age >60 years 20 (83.3) 32 (50.8) 0.007
WHO Score ≥2 20 (83.3) 34 (54) 0.024
No. of comorbidities>2 4 (16.7) 7 (11.1) 0.487
Diabetes 7 (29.2) 10 (15.9) 0.225
Corticosteroid treatment 9 (37.5) 15 (23.8) 0.283
Pulmonary antecedents 15 (62.5) 43 (68.3) 0.800
COPD 14 (58.3) 32 (50.8) 0.470
Severe COPD
(FEV1<30% theory)
1 (4.2) 2 (3.2) 1
Small cell cancer 6 (25) 17 (27) 1
More than 1 chemotherapy 4 (16.7) 10 (15.9) 1
Metastases 18 (75) 36 (57.1) 0.145
Radiotherapy associated 6 (25) 19 (30.2) 0.793
G-CSF preventive 4 (16.7) 13 (20.6) 0.771
G-CSF curative 12 (50) 19 (30.2) 0.132
Already hospitalized patient 7 (29.2) 5 (7.9) 0.017
Altered general status 17 (70.8) 30 (47.6) 0.059
Dehydration 14 (58.3) 20 (31.7) 0.029
Gravity signs at admission 15 (62.5) 29 (46) 0.231
Delayed treatment 6 (25) 12 (19) 0.562
Neutropenia > 8 days 3 (12.5) 6 (9.5) 0.702
Neutrophils count <100/mm3 7 (29.2) 13 (20.6) 0.354
Haemoglobin <8 g/dl 9 (37.5) 32 (50.8) 0.465
Platelets < 20000/mm3 10 (41.7) 8 (12.7) 0.006
Decreasing of CRP 8 (33.3) 32 (50.8) 0.002
Undetermined origin of fever 6 (25) 34 (54) 0.018
Clinically documented fever (without microbiological documentation) 6 (25) 8 (12.7) 0.196
Microbiologically documented fever 12 (50) 21 (33.3) 0.216
Respiratory signs 6 (25) 15 (23.8) 0.203
Bacteraemia 9 (37.5) 11 (17.5) 0.277
Gram negative bacilli 10 (41.7) 9 (14.2) 0.03
Multidrug resistant bacteria in patient with at least one strain documented 4 (33.3) 2 (9.5) 0.159
Antibiotic treatment in last 6 month 6 (25) 16 (25.8) 1
Out patient first antibiotic treatment 4 (16.7) 10 (15.9) 1
Appropriateness between microbiology and antibiotherapy in patient with at least one strain documented 7 (58.3) 21 (100) 0.003
  1. COPD = Chronic Obstructive Pulmonary Disease, CRP = C-reactive protein, FEV1 = Forced Expiratory Volume in first second, G-CSF = Granulocyte colony-stimulating factor, No = number.