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Table 4 Characteristics associated with mortality during follow-up in untreated HIV-infected children.

From: Severe morbidity and mortality in untreated HIV-infected children in a paediatric care programme in Abidjan, Côte d'Ivoire, 2004-2009

     

Univariate analysis

Ajusted analysis

        

Full model

Reduced model

Variable

# patients

# events

Observed rate (/100 CY)

sHR†

95%CI‡

P

sHR

95%CI

P

sHR

95%CI

P

Overall

 

405

21

3.26

         

Age at baseline (years)

     

0.034

  

0.840

  

0.097

 

< 1

64

9

9.70

1

-

 

1

-

 

1

-

 
 

[1 - 2]

42

2

3.40

0.32

(0.07 - 1.48)

 

0.76

(0.08 - 6.38)

 

0.6

(0.11 - 3.23)

 
 

[2 - 5]

108

3

1.68

0.2

(0.05 - 0.74)

 

0.44

(0.07 - 2.70)

 

0.34

(0.08 - 1.39)

 
 

[5 - 10]

142

5

1.82

0.24

(0.08 - 0.71)

 

0.39

(0.06 - 2.31)

 

0.29

(0.10 - 0.80)

 
 

[10 - 15]

49

2

4.91

0.28

(0.06 - 1.29)

 

0.44

(0.05 - 4.26)

 

0.28

(0.06 - 1.19)

 

Immunodeficiency

     

0.001

  

0.003

  

0.0025

 

No

112

6

1.36

1

-

 

1

-

 

1

-

 
 

Yes

106

2

3.38

5.21

(1.00 - 25.60)

 

6.8

(1.51 - 30.57)

 

6.02

(1.28 - 28.42)

 
 

Unknown

98

13

8.90

13.82

(3.16 - 60.50)

 

12.93

(2.95 - 56.68)

 

12.6

(2.94 - 53.97)

 

Gender

      

0.920

  

0.770

  

0.670

 

Male

216

11

3.09

1

-

 

1

-

 

1

-

 
 

Female

189

10

3.45

1.05

(0.47 - 2.45)

 

1.15

(0.44 - 2.98)

 

1.22

(0.49 - 3.04)

 

History of a PMTCT intervention

    

0.019

  

0.590

   
 

No

267

11

2.80

1

-

 

1

-

    
 

Yes

65

8

6.73

2.96

(1.19 - 7.33)

 

0.92

(0.14 - 6.21)

    
 

Unknown

73

2

1.48

0.63

(0.14 - 2.83)

 

0.47

(0.11 - 2.05)

    

Mother known to be deceased

    

0.140

  

0.230

   
 

No

308

19

3.59

1

-

 

1

-

    
 

Yes

97

2

1.72

3.01

(0.71 - 12.80)

 

2.78

(0.53 - 14.68)

    

Cotrimoxazole prophylaxis at baseline

   

0.150

  

0.830

   
 

No

134

11

4.93

1

-

 

1

-

    
 

Yes

271

10

2.36

0.53

(0.23 - 1.25)

 

1.13

(0.37 - 3.43)

    

Follow-up Centre

     

0.550

      
 

Cepref

131

15

3.34

1

-

       
 

MTCT

92

6

3.05

1.33

(0.52 - 3.45)

       
  1. Children followed-up over 18 months by the CePReF and the MTCT-Plus programme, Abidjan, Côte d'Ivoire (January-2004-December 2009). n = 405. Fine and Gray Model. CY: Child Years; †sHR: subdistribution hazard ratio; ‡95% confidence interval