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Table 3 Characteristics associated with the first severe morbidity during follow-up in untreated HIV-infected children.

From: Severe morbidity and mortality in untreated HIV-infected children in a paediatric care programme in Abidjan, Côte d'Ivoire, 2004-2009

      Univariate analysis Ajusted analysis
         Full model Reduced model
Variable # patients # events Observed rate (/100 CY) sHR† 95%CI‡   sHR 95%CI P sHR 95%CI P
Overall   405 58 17.80          
Age at baseline (years)       0.54    0.39    0.07
  < 1 64 7 12.78 1 -   1 -   1 -  
  [1 - 2] 42 7 20.36 1.29 (0.47-3.58)   0.45 (0.12 - 1.64)   0.52 (0.13 - 2.01)  
  [2 - 5] 108 17 20.41 1.24 (0.53 - 2.91)   0.43 (0.14 - 1.31)   0.42 (0.14 - 1.32)  
  [5 - 10] 142 21 16.65 0.94 (0.41 - 2.15)   0.38 (0.13 - 1.14)   0.30 (0.10 - 0.97)  
  [10 - 15] 49 4 14.58 0.45 (0.12 - 1.70)   0.23 (0.05 - 1.02)   0.15 (0.03 - 0.66)  
Immunodeficiency       0.87    0.91    0.86
  No 112 29 13.61 1 -   1 -   1 -  
  Yes 106 15 39.24 0.84 (0.43-1.63   0.88 (0.47 - 1.65)   0.84 (0.43 - 1.63)  
  Unknown 98 14 18.75 0.91 (0.46 - 1.77)   1.02 (0.54 - 1.93)   1.03 (0.51 - 2.07)  
Gender        0.78    0.95    0.77
  Male 216 32 18.07 1 -   1 -   1 -  
  Female 189 26 17.46 0.93 (0.54 - 1.60)   0.91 (0.54 - 1.58)   0.91 (0.51 - 1.61)  
History of a PMTCT intervention      0.11    0.19    0.05
  No 267 41 21.72 1 -   1 -   1 -  
  Yes 65 5 7.41 0.43 (0.15 - 1. 02)   0.32 (0.06 - 1. 63)   0.16 (0.04 - 0.72)  
  Unknown 73 12 17.20 1.04 (0.53 - 2.02)   1.21 (0.56 - 2.59)   0.82 (0.42 - 1.59)  
Mother known to be deceased      0.13    0.26    
  No 308 48 18.19 1 -   1 -     
  Yes 97 10 16.10 1.78 (0.84 - 3.14)   1.51 (0.73 - 3.09)     
Cotrimoxazole prophylaxis at baseline     0.35       
  No 134 17 15.60 1 -        
  Yes 271 41 18.89 1.33 (0.73 - 2.43)        
Follow-up Centre       0.05    0.14    
  Cepref 131 50 21.92 1 -   1 -     
  MTCT 92 8 8.17 0.43 (0.18 - 1)   0.45 (0.16 - 1.29)     
  1. Children followed-up over 18 months by the CePReF and the MTCT-Plus programme, Abidjan, Côte d'Ivoire (January-2004-December 2009). n = 405. Fine and Gray Model CY: Child Years; †sHR: subdistribution hazard ratio; ‡95% confidence interval