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Table 2 Antibiotic dosage and outcome data of eligible studies included in a meta-analysis of prolonged infusion versus intermittent infusion of β-lactams in hospitalized patients

From: Does prolonged β-lactam infusions improve clinical outcomes compared to intermittent infusions? A meta-analysis and systematic review of randomized, controlled trials

   Antibiotic Dose and Infusion Schedule Number Randomized Number Analyzed Adverse Effects
Study Antibiotic Intermittent Prolonged Intermittent Prolonged Intermittent Prolonged Definition Intermittent n, % Prolonged n, %
Angus 2000 Ceftazidime 40 mg/kg q8 h 4 mg/kg/h over 24 h; 12 mg/kg LD over 30 min* 11 10 11 10 Not specified NA NA
Bodey 1979 Cefamandole 3 g q6 h 12 g over 24 h; 3 g LD over 30 min 92 74 92 74 Renal failure 17 (18) 14 (19)
Buck 2005 Piperacillin/Tazobactam 4 g/0.5 g q8 h 8 g over 24 h; 2 g LD over 60 min 12 12 12 12 Not specified NA NA
Georges 2005 Cefepime 2 g q12 h 2 g q12 h over 12 h 24 26 24 26 Bacterial superinfection 4 (17) 3 (12)
Hanes 2000 Ceftazidime 2 g q8 h 60 mg/kg over 24 h; 2 g LD over 30 min 15 17 14 16 Bacterial superinfection 3 (22) 7 (44)
Kojika 2005 Meropenem 0.5 g q8 h 0.5 g q8 h over 3 h 5 5 5 5 Hepatotoxicity or renal failure 0 0†††
Lagast 1983 Cefoperazone 2 g q12 4 g over 24 h; 1 g LD over 15 min 25 20 25 20 Diarrhea, phlebitis, skin rash NA NA
Lau 2006 Piperacillin/Tazobactam 3 g/0.375 g q6 h 12 g/1.5 g over 24 h; 2 g LD over 30 min 132 130 130 128 Gastrointestinal and CNS disturbances 115 (87) 116 (89)
Lubasch 2003 Ceftazidime 2 g q8 h 2 g q12 h over 7 h; 2 g LD over 30 min 40 41 40 41 Gastrointestinal and CNS disturbances NA NA
Merchant 2008 Doripenem & Imipenem Imipenem 500 mg q6 h min;1 g q8 h Doripenem 500 mg q8 h over 4 h 267 264 252 249 Hepatotoxicity, diarrhea, rash, nausea 21 (8) 24 (10)
Nicolau 2001 Ceftazidime 2 g q8 h 3 g over 24 h; 1 g LD over 30 min 19 22 18 17 Diarrhea, rash NA NA
Rafati 2006 Piperacillin 3 g q6 h 8 g over 24 h; 2 g LD over 30 min 20 20 20 20 Not specified NA NA
Roberts 2007 Ceftriaxone 2 g q24 h 2 g over 24 h; 0.5 g LD as "bolus" 28 29 28 29 Renal failure NA NA
Van Zanten 2006 Cefotaxime 1 g q8 h 2 g over 24 h; 1 g LD over 30 min 46 47 43 40 Not specified NA NA
  1. *LD - loading dose