Table 1 Hepatitis B virus polymerase gene variants characterized by clonal analysis during the follow-up
Sampling date | Treatment | Resistance mutations* |
|---|---|---|
Jun-98 | IFN | wt |
Feb-01 | LMV | (15/15) M204I |
May-01 | No | (14/15) wt + (1/15) I233V |
May-02 | No | ND |
Nov-03 | LMV | ND |
Sep-04 | LMV | ND |
Ago-05 | LMV | ND |
Jul-06 | ADF | (15/15) L180M/M204I |
Dec-08 | ETV+TDF | (17/18) L180M/M204I + (1/18) T184L |
May-09 | ETV+TDF | (13/15) L180M/M204I + (1/15) T184L + (1/15) A181T |
Nov-09 | ETV+TDF | (15/15) L180M/M204I |