Figure 1From: Unsuccessful therapy with adefovir and entecavir-tenofovir in a patient with chronic hepatitis B infection with previous resistance to lamivudine: a fourteen-year evolution of hepatitis B virus mutations HBV viral load dynamics (black squares) and course of aminotransferase -ALT- (black triangles) levels during different treatment (IFN: interferon; LMV: lamivudine; ADV: adefovir; ETV: entecavir; TDF: tenofovir). In the superior panel the HBeAg/antiHBe profile during the follow-up is depicted; the asterisk (*) denotes the period exhibiting reversion to HBeAg (+) and anti-HBe (-). In the inferior panel, solid black arrows indicate sampling times for HBV pol gene clonal analysis (see also Table 1).Back to article page