Skip to main content

Advertisement

Table 2 Comparison of the performance of the Tubex® test from published reports

From: Assessment and comparative analysis of a rapid diagnostic test (Tubex®) for the diagnosis of typhoid fever among hospitalized children in rural Tanzania

Author Year Journal Sample Size Location Tubex ® cut off Sens Spec True neg . definition Reader Gold standard Study population
Ley, B. et al This paper This Journal 139 Tanzania >4 79% 89% All non-typhi bacteriamia Investigator Blood Culture (BACTEC) >2 months + >37.5° (inpatients) & history of fever (outpatients)
    88    79% 97% All non-salmonella bacteriamia    
Naheed, A. et al 2008 Diagn Microbiol Infect Dis. 867 Bangladesh ≥4 60% 58% Other confirmed bacteremia ICDDRB lab Manual Blood Culture Active surveillance
Temp ≥38°C
       60% 64% Blood culture neg & other bacteremia    
Rahman, M. et al 2007 Diagn Microbiol Infect Dis. 243 Bangladesh >4 91.2% 82.3% Other febrile patients ICDDRB lab, min. 2 independent lab techs Manual Blood Culture Outpatients, all ages with history of fever
       No. Pos 89.5% Healthy subjects    Healthy subjects
Dong, B. et al 2007 Epidemiol. Infect. 1732 China ≥2 100% 43% Paratyphoid cases - Blood culture (BACTEC) Age 5-60 with reported history of fever for 3 days
      ≥4 69% 95%     
      ≥6 62% 95%     
      ≥8 23% 100%     
      ≥10 15% 100%     
Kawano, R. L. et al 2006 JCM. 177 Philippines ≥2 94.7% 80.4% Blood culture neg. n/A Manual Blood Culture &BACTEC Clinically suspected typhoid cases
Dutta, S. et al 2006 Diagn Microbiol Infect Dis. 495 India ≥4 56% 88% Paratyphoid and malaria cases n/A Blood Culture BACTEC Outpatients, all ages, Pat with history of fever for 3 days
Ohlsen, S. J. et al 2004 JCM. 79 Vietnam According to protocol 78% 94% Other lab-confirmed febrile illnesses n/A Manual Blood Culture/BACTEC Pat ≥3 year and history of ≥4 day fever
House, D. et al 2001 JCM. 127 Vietnam >2 87% 76% Febrile hospitalized patients labtech Culture Children and adults
Lim et al 1998 JCM. 105 Hong Kong & Malaysia >2 100% 100% Healthy individuals and pat with other bacterial diseases and autoimmune disease labtechs Culture confirmed (56% of pos.), clinical picture, various other tests Clinical picture, culture confirmed,