Table 2 Comparison of the performance of the Tubex® test from published reports
Author | Year | Journal | Sample Size | Location | Tubex ® cut off | Sens | Spec | True neg . definition | Reader | Gold standard | Study population |
|---|---|---|---|---|---|---|---|---|---|---|---|
Ley, B. et al | This paper | This Journal | 139 | Tanzania | >4 | 79% | 89% | All non-typhi bacteriamia | Investigator | Blood Culture (BACTEC) | >2 months + >37.5° (inpatients) & history of fever (outpatients) |
88 | 79% | 97% | All non-salmonella bacteriamia | ||||||||
Naheed, A. et al | 2008 | Diagn Microbiol Infect Dis. | 867 | Bangladesh | ≥4 | 60% | 58% | Other confirmed bacteremia | ICDDRB lab | Manual Blood Culture | Active surveillance Temp ≥38°C |
60% | 64% | Blood culture neg & other bacteremia | |||||||||
Rahman, M. et al | 2007 | Diagn Microbiol Infect Dis. | 243 | Bangladesh | >4 | 91.2% | 82.3% | Other febrile patients | ICDDRB lab, min. 2 independent lab techs | Manual Blood Culture | Outpatients, all ages with history of fever |
No. Pos | 89.5% | Healthy subjects | Healthy subjects | ||||||||
Dong, B. et al | 2007 | Epidemiol. Infect. | 1732 | China | ≥2 | 100% | 43% | Paratyphoid cases | - | Blood culture (BACTEC) | Age 5-60 with reported history of fever for 3 days |
≥4 | 69% | 95% | |||||||||
≥6 | 62% | 95% | |||||||||
≥8 | 23% | 100% | |||||||||
≥10 | 15% | 100% | |||||||||
Kawano, R. L. et al | 2006 | JCM. | 177 | Philippines | ≥2 | 94.7% | 80.4% | Blood culture neg. | n/A | Manual Blood Culture &BACTEC | Clinically suspected typhoid cases |
Dutta, S. et al | 2006 | Diagn Microbiol Infect Dis. | 495 | India | ≥4 | 56% | 88% | Paratyphoid and malaria cases | n/A | Blood Culture BACTEC | Outpatients, all ages, Pat with history of fever for 3 days |
Ohlsen, S. J. et al | 2004 | JCM. | 79 | Vietnam | According to protocol | 78% | 94% | Other lab-confirmed febrile illnesses | n/A | Manual Blood Culture/BACTEC | Pat ≥3 year and history of ≥4 day fever |
House, D. et al | 2001 | JCM. | 127 | Vietnam | >2 | 87% | 76% | Febrile hospitalized patients | labtech | Culture | Children and adults |
Lim et al | 1998 | JCM. | 105 | Hong Kong & Malaysia | >2 | 100% | 100% | Healthy individuals and pat with other bacterial diseases and autoimmune disease | labtechs | Culture confirmed (56% of pos.), clinical picture, various other tests | Clinical picture, culture confirmed, |