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Table 1 Summary of 26 patients with rheumatoid arthritis who developed histoplasmosis infection

From: Histoplasmosis infection in patients with rheumatoid arthritis, 1998-2009

Characteristic Number (%) or years
Male 15 (58%)
Age, years (mean; range) 60 (32 - 78)
Duration of rheumatoid arthritis, years (mean; range) 10.5 (0.5 - 24)
Current disease modifying antirheumatic drug therapy 25 (96%)
Hospitalized for infection 15 (58%)
Duration of follow up, years (mean; range) 2.1 (0 - 7.9)
Patient deaths 2 (5%)
Medication Number (%)
Methotrexate 21 (81%)
Prednisone (average dose: 9.1 mg) 15 (58%)
Hydroxychloroquine 5 (19%)
Leflunomide 5 (19%)
Anti-TNF Agent 15 (58%)
   Adalimumab 7 (27%)
   Infliximab 6 (23%)
   Etanercept 2 (8%)
Basis for Histoplasmosis Diagnosis Number positive (%)
Fever 19 (73%)
Abnormal chest imaging (X-ray or CT) 22 (85%)
Histoplasma serology 23 (88%)
Histoplasma culture 14 (54%)
Histoplasma urinary antigen 13 (50%)
Histoplasma biopsy histopathology 12 (46%)