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Table 1 Scale for grading the disease severity in patients with HFRS

From: Serum levels of inflammatory and regulatory cytokines in patients with hemorrhagic fever with renal syndrome

Signs and symptoms

 

Score

1. SHOCK, HYPOTENSION a

  

Shock

 

10

Hypotension, systolic blood pressure < 90 mm Hg

 

5

Tachycardia, heart rate > 120/min

 

2

2. HAEMORRHAGES a

  

Massive: blood transfusion needed

 

5

Internal (melena, hematemesis, hemoptysis, intracranial)

 

3

Epistaxis

 

2

Petechiae, conjuctival injection, enanthema

 

1

3. GENERAL SYMPTOMS

  

Body temperature > 40°C

 

2

Seizure

 

2

Blurred vision

 

1

Vomiting and diarrhea

 

1

Anuria/oliguria

 

1

Dialysis requirement

 

1

4. Laboratory parameters

  

Serum urea and/or creatinine

> 5-times the normal value

5

 

> 4-times the normal value

4

 

> 3-times the normal value

3

 

> 2-times the normal value

2

Trombociti

< 20 × 109/L

2

 

< 50 × 109/L

1

AST, ALT

> 5-times the normal value

2

 

3-4-times the normal value

1

Lung X-ray

pneumonitis

2

 

pleural effusion

1

  1. a In group 1 and 2, only the signs/symptoms with the highest score are considered