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Table 2 Host and viral baseline parameters in patients with and without treatment response

From: Core mutations, IL28B polymorphisms and response to peginterferon/ribavirin treatment in Swedish patients with hepatitis C virus genotype 1 infection

 

SVR

n = 29

non-SVR

n = 21

Univariate

p value

Age (mean)

45.2

48.8

0.09a

   Number of patients < 45 / > 45 yrs

11 / 18

4 / 17

0.21b

Gender (m/f)

17 / 12

13 / 8

1.0b

Baseline HCV RNA (mean log IU/mL)

6.37

6.59

0.56a

   Number with < 5.6 / > 5.6 log IU/mL

8 / 21

0 / 21

0.01b

Genotype 1a/1b

21 / 8

16 / 5

1.0b

Fibrosis (F0/F1/F2/F3/F4)c

0 / 10 / 13 / 4 / 0

2 / 4 / 4 / 7 / 2

0.19d

Core aa 70

28 R / 1 Q

15 R / 5 Q & 1 P

0.03b

Core aa 91

21 C / 6 M / 2 L

16 C / 3 M / 2 L

0.82e

rs12979860

16 CC / 13 CT / 0 TT

2 CC / 11 CT / 8 TT

0.0001e

  1. a Mann-Whitney U test.
  2. b Fisher's exact test.
  3. c Fibrosis was scored according to Ludwig and Batts, and was available for 34 patients.
  4. d Logistic regression.
  5. e Chi square test.