Ureaplasma parvum infection alters filamin a dynamics in host cells

BMC Infectious Diseases

Table 1 List of proteins found to be perturbed in animals with active U. parvum infection^a).

Accession^b)	Protein name	Gene Ontology Biological Process^c)	Effect^d)
IPI00194097.5	Gc Vitamin D-binding protein	transports vitamin D and its metabolites	↑
IPI00193485.2	Isocitrate dehydrogenase [NADP]	carbohydrate metabolism	↓
IPI00767147.1	Similar to Alpha-enolase	carbohydrate metabolism	↓
IPI00195372.1	Elongation factor 1-alpha 1	protein biosynthesis/translational elongation	↓
IPI00231358.6	Profilin - 1	actin binding	↑
IPI00454431.1	Brain-specific alpha actinin 1	actin binding	↓
IPI00365286.3	Similar to Vinculin	cell motility/cell adhesion/lamellipodium biogenesis	↓
IPI00409539.3	Similar to Filamin-A	actin filament binding/actin cytoskeleton reorganization/glycoprotein binding/cytoplasmic sequestering of protein/regulation of transcription factor/regulation of I-kappa β kinase/NF-κβ cascade	↓

a) Proteins found to be significantly altered by both enrichment analysis (Figure 1A and B) and ANOVA (Figure 1b).
b) Accession numbers refer to the International Protein Database, http://www.ebi.ac.uk/IPI/IPIhelp.html.
c) Gene ontology data was obtained from the Panther database http://www.pantherdb.org and the UniprotKB/Swiss-Prot Database http://www.ebi.ac.uk/uniprot.
d) Effect refers to the protein ratio that was generated by the ProGroup™ algorithm, which compared actively infected animals (UTI and Struvite groups) to Negative group or Control group. Actual protein ratios are listed in Additional file 1, tables S1 and S2.

ISSN: 1471-2334