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Table 3 vivo kinetics of killing of C. elegans infected by E. coligrown in urine samples after consumption of the different proanthocyanidins regimens.

From: Dosage effect on uropathogenic Escherichia coli anti-adhesion activity in urine following consumption of cranberry powder standardized for proanthocyanidin content: a multicentric randomized double blind study

A LT50 Median (IC95%) in days P
Regimen Placebo 18 mg 36 mg 72 mg Pl vs 18/36 18 vs 36 36 vs 72 6 h vs 24 h Sp-Fr vs Ja-Hu
Spain          
   1-6 h 3.5 [3-5] 5 [3-7] 6 [5-8] ND <0.001 <0.001 ND NS except for 72 mg  
   24 h 3 [3-6] 4.5 [3-6] 5 [3-6] ND <0.001 NS ND <0.001  
France          <0.001
   1-6 h 3 [3-5] 5 [4-7] 5.5 [4-7] ND <0.001 NS ND NS except for 36 mg  
   24 h 3 [3-5] 3 [2-4] 5 [4-8] ND NS <0.001 ND <0.001  
Japan          
   1-6 h 4 [3-5] ND 6.5 [5-9] 7 [5-9] <0.001 ND NS NS  
   24 h 4 [3-5] ND 5.5 [4-8] 6 [4-8] <0.001 ND NS   
<0.001          
Hungary          
   1-6 h 3 [3-5] ND 5 [4-8] 6 [5-10] <0.001 ND NS NS  
   24 h 4 [3-5] ND 5 [4-8] 6 [4-9] <0.001 ND NS   
Total          
   1-6 h 3 [3-5] 5 [3-7] 5.5 [4-9] 6.5 [5-10] <0.001 NS <0.001 NS ND
   24 h 3.5 [3-5] 4 [2-6] 5 [3-8] 6 [4-9] <0.001 <0.001 <0.001   ND
OP50 6 [6-7]         
B LT100 Median (IC95%) in days P        
Regimen Placebo 18 mg 36 mg 72 mg Pl vs 18/36 18 vs 36 36 vs 72 6 h vs 24 h Sp-Fr vs Ja-Hu
Spain          
   1-6 h 8.5 [7-8] 10 [9-10] 11.5 [11-12] ND <0.001 <0.001 ND NS except for 72 mg <0.001
   24 h 7 [6-8] 9 [8-10] 9.5 [9-10] ND <0.001 NS ND <0.001  
France          
   1-6 h 7 [6-8] 10 [9-11] 11 [10-12] ND <0.001 NS ND NS except for 36 mg  
   24 h 7 [6-8] 8 [7-9] 10.5 [10-11] ND NS <0.001 ND <0.001  
Japan          <0.001
   1-6 h 8 [7-8] ND 12.5 [12-13] 13 [12-14] <0.001 ND NS NS  
   24 h 7.5 [7-8] ND 11 [10-12] 12 [11-13] <0.001 ND NS   
Hungary          
   1-6 h 7 [6-8] ND 12 [11-13] 12.5 [12-13] <0.001 ND NS NS  
   24 h 8 [7-8] ND 11 [10-12] 11.5 [11-12] <0.001 ND NS   
Total          
   1-6 h 7 [6-8] 5 [3-7] 5.5 [4-9] 6.5 [5-10] <0.001 NS <0.001 NS ND
   24 h 8 [7-8] 4 [2-6] 5 [3-8] 6 [4-9] <0.001 <0.001 <0.001   ND
OP50 14 [13-15]         
  1. (A) Determination of LT50 Median; (B) Determination of LT100 Median.