Dynamic models of pneumococcal carriage and the impact of the Heptavalent Pneumococcal Conjugate Vaccine on invasive pneumococcal disease

Table 1 Model parameters

	Base case	Range	Source
Duration of carriage (days):			[41, 42]
0-1 y	72
2-4 y	28
5-17 y	18
18+ y	17
c_V	0.5	0-1	[41]
c_N	0.85*	0.5-1	*Fitted to US data
ε, mixing pattern	0.87*	0.7-0.95	*Fitted to US data
1/ω, average duration of protection	8.3 y*	5-20 y^#	*Fitted to US data ^#95% CI estimated
γ, degree of protection	0.756*	69-84%^{#^}	*Fitted to US data ^#95% CI estimated

^duration and degree of protection are correlated; i.e. short duration is paired with high protection
Transmission parameters of pneumococcal carriage for the base case and ranges used in the sensitivity analyses.

ISSN: 1471-2334