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Table 1 Baseline characteristics and microbiologic confirmation of tuberculosis in 209 HIV-1 infected and 83 HIV-1 uninfected patients receiving antituberculosis treatment

From: Clinical deterioration during antituberculosis treatment in Africa: Incidence, causes and risk factors

 

HIV-1 infected (n = 209)

HIV-1 uninfected (n = 83)

p-value

Female, n (%)

112 (54)

25 (30)

<0.001

Age in years, median (IQR)

35 (30-41)

38 (29-49)

0.035

CD4 count at TB diagnosis, n (%):

   

>350 cells/mm 3

36 (17)

-

 

200 - 350 cells/mm 3

37 (18)

-

 

< 200 cells/mm 3

133 (64)

-

 

Not performed

3 (1)

-

 

Previous TB, n (%)

71 (34)

19 (23)

0.070

TB diagnosed at referral hospital, n (%):

79 (38)

13 (16)

<0.001

Microbiologic confirmation at TB diagnosis 1 , n (%)

123 (59)

68 (82)

<0.001

Drug susceptibilities known at TB diagnosis 1 , n (%)

67 (32)

49 (59)

<0.001

Culture sent at TB diagnosis, n (%)

169 (81)

68 (82)

1.000

Extra-pulmonary TB, n (%):

82 (39)

14 (17)

<0.001

Weight at TB diagnosis in kg, median (IQR)

54 (49-62)

54 (49-64)

0.644

Microbiologic confirmation at TB diagnosis and during 24 weeks of follow-up 2 , n (%)

153 (73)

70 (84)

0.048

Drug susceptibilities known at TB diagnosis and during 24 weeks of follow-up 2 , n (%)

117 (56)

57 (69)

0.296

Culture sent at TB diagnosis and/or during 24 weeks of follow-up, n (%)

190 (91)

76 (92)

1.000

  1. Key:
  2. 1 within 14 days of TB diagnosis. No TB specimens sent in 12 HIV-1 infected patients and 3 HIV-1 uninfected patients at TB diagnosis.
  3. 2 no TB specimens sent in 2 HIV-1 infected patients.
  4. TB = tuberculosis, IQR = inter-quartile range, OR = odds-ratio, 95% CI = 95% confidence interval