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Figure 2 | BMC Infectious Diseases

Figure 2

From: Distinct genotypic profiles of the two major clades of Mycobacterium africanum

Figure 2

Summary diagram and phylogenetic postitions of the genomic markers interrogated against the Ghana MTC strain collection. Shown are the various major divisions of the MTC segregated according to the presence or absence of inter-species-, intra-species-, and sublineage-specific polymorphisms. Circles are placed at points in evolutionary history beyond which each strain that was evaluated possessed a consistent set of polymorphisms. The nodes are numbered in the figure as follows to denote: 1. RD12can, 3' cfp32 deletion; 2. TbD1, narGHJI -215; 3. pks15/1 (7-bp deletion), katG 463; 4. undefined deletion at the RDRio/MiD3 locus; 5. gyrA 95; 6. RD9, gyrB 1450; 7. RD713, TbD1197, aroA 285, Rv1332 523; 8. RD711; 9. RD7, RD8, RD10, pks15/1 (6-bp deletion), katG 203, 3'cfp32 311, RD13174, PPE55 2148, PPE55 2154; 10. Rv1510 1129; 11. RD701, RD702, hsp65 540, nat 751; 12. rpoB 1163; 13. rpoB 1049; 14. RD1das; 15. mmpL6 551; 16. MiD3; 17. RD12, RD13; 18. RD4; 19. RD1BCG. Lineages that include strains from the Ghana collection are terminated with arrowheads. Note that distances are arbitrary and do not reflect the number of phylogenetically relevant polymorphisms present at each juncture. TbD1-positive M. tuberculosis is also known as "ancient" M. tuberculosis and TbD1-negative M. tuberculosis is also known as "modern" M. tuberculosis [1]. WA - West African.

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