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Table 2 Antimicrobial activity of meropenem, imipenem and piperacillin/tazobactam against 1071 pathogens determined by agar dilution reference method.

From: Comparative in vitro activity of Meropenem, Imipenem and Piperacillin/tazobactam against 1071 clinical isolates using 2 different methods: a French multicentre study

Species (number tested) MICs (mg/L) % Susceptiblity
Drugs     
  MIC50 MIC90 Range EUCAST
Escherichia coli (139)     
Meropenem 0.016 0.016 0.016-0.032 100
Imipenem 0.064 0.125 0.032-0.5 100
Piperacillin/tazobactam* 2 8 0.25-128 90
Enterobactericeae (other than E coli) (139)
Meropenem 0.032 0.064 0.016-16 99
Imipenem 0.125 1 0.032-16 98
Piperacillin/tazobactam* 2 16 0.125-128 90
Pseudomonas aeruginosa (129)
Meropenem 0.5 4 0.064-16 84
Imipenem 2 16 0.5-32 84
Piperacillin/tazobactam* 8 32 0.25-256 90
Acinetobacter (86)
Meropenem 0.5 2 0.125-16 94
Imipenem 0.5 1 0.125-8 98
Piperacillin/tazobactam* 0.032 2 0.032-16 100*
Other non fermentative bacteria (30)
Meropenem 0.5 2 0.03-16 93
Imipenem 1 2 0.125-8 97
Piperacillin/tazobactam* 2 8 0.032-64 96
Staphylococcus aureus (susceptible to methicillin) (145)
Meropenem 0.125 0.125 0.032-1 100
Imipenem 0.032 0.064 0.016-0.25 100
Piperacillin/tazobactam* 1 2 0.064-8 100
Coagulase negative staphylococci (susceptible to methicillin) (129)
Meropenem 0.064 0.125 0.032-0.5 100
Imipenem 0.016 0.032 0.008-0.125 100
Piperacillin/tazobactam* 0.5 1 0.016-2 100
Streptococcus pneumoniae (136)
Meropenem 0.016 0.25 0.016-0.25 100
Imipenem 0.016 0.125 0.016-0.25 100
Piperacillin/tazobactam* 0.25 4 0.016-8 100
Anaerobes (138)
Meropenem 0.032 0.5 <0.016-4 100
Imipenem 0.064 0.5 <0.016-8 100
Piperacillin/tazobactam* 0.5 8 <0.016-32 100
  1. *Tazobactam: 4 mg/L