Comparative in vitro activity of Meropenem, Imipenem and Piperacillin/tazobactam against 1071 clinical isolates using 2 different methods: a French multicentre study

Table 2 Antimicrobial activity of meropenem, imipenem and piperacillin/tazobactam against 1071 pathogens determined by agar dilution reference method.

Species (number tested)	MICs (mg/L)			% Susceptiblity
Drugs
	MIC50	MIC90	Range	EUCAST
Escherichia coli (139)
Meropenem	0.016	0.016	0.016-0.032	100
Imipenem	0.064	0.125	0.032-0.5	100
Piperacillin/tazobactam*	2	8	0.25-128	90
Enterobactericeae (other than E coli) (139)
Meropenem	0.032	0.064	0.016-16	99
Imipenem	0.125	1	0.032-16	98
Piperacillin/tazobactam*	2	16	0.125-128	90
Pseudomonas aeruginosa (129)
Meropenem	0.5	4	0.064-16	84
Imipenem	2	16	0.5-32	84
Piperacillin/tazobactam*	8	32	0.25-256	90
Acinetobacter (86)
Meropenem	0.5	2	0.125-16	94
Imipenem	0.5	1	0.125-8	98
Piperacillin/tazobactam*	0.032	2	0.032-16	100*
Other non fermentative bacteria (30)
Meropenem	0.5	2	0.03-16	93
Imipenem	1	2	0.125-8	97
Piperacillin/tazobactam*	2	8	0.032-64	96
Staphylococcus aureus (susceptible to methicillin) (145)
Meropenem	0.125	0.125	0.032-1	100
Imipenem	0.032	0.064	0.016-0.25	100
Piperacillin/tazobactam*	1	2	0.064-8	100
Coagulase negative staphylococci (susceptible to methicillin) (129)
Meropenem	0.064	0.125	0.032-0.5	100
Imipenem	0.016	0.032	0.008-0.125	100
Piperacillin/tazobactam*	0.5	1	0.016-2	100
Streptococcus pneumoniae (136)
Meropenem	0.016	0.25	0.016-0.25	100
Imipenem	0.016	0.125	0.016-0.25	100
Piperacillin/tazobactam*	0.25	4	0.016-8	100
Anaerobes (138)
Meropenem	0.032	0.5	<0.016-4	100
Imipenem	0.064	0.5	<0.016-8	100
Piperacillin/tazobactam*	0.5	8	<0.016-32	100

ISSN: 1471-2334