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Table 3 Geometric means for antibody potency and antibody needed for 1:8 opsonization index (Elderly, N = 33; Adults, N = 24)

From: The effect of age on the response to the pneumococcal polysaccharide vaccine

Serotype Age Pre-Antibody potency (OT/[IgG]) Post-Antibody potency (OT/[IgG]) Pre-Antibody needed for 1:8 opsonization index (ng/ml) Post-Antibody needed for 1:8 opsonization index (ng/ml)
   GMP 95% CI Sig GMP 95% CI Sig GMI Sig GMI Sig
4 Adult 42 16-111 NS 633 372-1076 P < 0.05 191.4 NS 12.6 P < 0.05
  Elderly 37 18-73   171 77-378   218.6   46.7  
6B Adult 343 102-1153 NS 1349 743-2451 NS 23.3 NS 5.9 NS
  Elderly 150 57-392   710 418-1209   53.5   11.3  
9V Adult 458 145-1448 NS 1112 554-2233 NS 17.5 NS 7.2 NS
  Elderly 324 126-834   813 466-1417   24.7   9.8  
14a Adult 63 23-172 NS 423 202-886 NS 126.1 NS 18.9 NS
  Elderly 248 71-860   426 211-859   32.3   18.8  
18C Adult 641 242-1699 NS 1440 951-2182 NS 12.5 NS 5.6 NS
  Elderly 286 121-677   990 655-1497   28.0   8.1  
19A Adult ND   ND ND   ND ND ND ND ND
  Elderly ND    ND    ND    
19F Adult 12 5-30 NS 276 195-391 P < 0.05 653.2 NS 29.0 P < 0.05
  Elderly 15 7-31   165 128-212   535.7   48.5  
23F Adult 789 309-2012 NS 982 650-1482 P < 0.05 10.1 NS 8.1 P < 0.05
  Elderly 386 170-879   571 396-824   20.7   14.0  
6A Adult 32 11-96 P < 0.05 888 444-1774 P < 0.05 249.1 P < 0.05 9.0 P < 0.05
  Elderly 5 3-11   61 28-134   1486.5   131.3  
  1. pre vs post P < 0.05
  2. a For Pn 14 OPKA was done in a limited patients due to lack of sera {Adults (N = 10), Elderly (N = 20)}.