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Table 1 Geometric means for antibody concentration and opsonization titers (Elderly, N = 33; Adults, N = 24)

From: The effect of age on the response to the pneumococcal polysaccharide vaccine

Serotype Age Pre-IgG concentration (μg/mL) Post-IgG concentration (μg/mL) Pre-Opsonic titer (OT) Post-Opsonic titer (OT)
   GMC 95% CI Sig GMC 95% CI Sig GMT 95% CI Sig GMT 95% CI Sig
4 Adult 0.43 0.32-0.59 P < 0.05 2.21 1.61-3.05 P < 0.05 17 6-47 NS 1300 694-2437 P < 0.05
  Elderly 0.27 0.22-0.34   1.29 0.88-1.89   10 5-20   220 85-569  
6B Adult 1.06 0.75-1.50 NS 6.17 3.51-10.85 NS 364 104-1270 NS 8023 5747-11202 NS
  Elderly 1.17 0.85-1.61   7.73 4.13-14.48   175 65-473   5495 3823-7898  
9V Adult 1.08 0.66-1.77 NS 6.05 4.22-8.68 NS 504 136-1867 NS 6380 3097-13140 P = 0.05
  Elderly 0.71 0.51-0.99   5.54 3.62-8.49   229 81-649   4506 2654-7649  
14a Adult 3.02 1.56-5.86 NS 18.7 9.91-35.29 NS 237 71-795 NS 6036 4091-8907 P < 0.05
  Elderly 1.92 1.26-2.93   10.12 6.47-15.83   579 192-1748   4673 2298-9501  
18C Adult 1.10 0.72-1.67 NS 5.8 3.53-9.52 NS 675 236-1931 NS 7226 5167-10105 NS
  Elderly 0.95 0.64-1.42   6.77 4.42-10.37   273 104-717   6698 4481-10012  
19A Adult ND   ND ND   ND 59 21-170 NS 2995 1919-4675 P < 0.05
  Elderly ND    ND    27 12-58   556 252-1227  
19F Adult 3.28 2.38-4.52 NS 8.42 5.42-13.1 NS 40 15-105 NS 2082 1409-3075 NS
  Elderly 2.87 2.17-3.81   7.18 5.18-9.95   43 19-97   1183 759-1843  
23F Adult 0.60 0.37-0.99 NS 3.22 1.91-5.41 NS 485 183-1286 NS 3101 2027-4746 NS
  Elderly 0.70 0.48-1.01   5.8 3.64-9.23   269 111-653   3314 2152-5101  
6A Adult 1.62 1.19-2.22 P < 0.05 2.39 1.78-3.21 NS 54 17-171 NS 2097 1041-4226 P < 0.05
  Elderly 3.25 2.21-4.79   4.01 2.81-5.72   17 9-36   244 102-587  
  1. pre vs post P < 0.05
  2. aFor Pn 14 OPKA was done in a limited patients due to lack of sera {Adults (N = 10), Elderly (N = 20)}