The effect of age on the response to the pneumococcal polysaccharide vaccine

BMC Infectious Diseases

Table 1 Geometric means for antibody concentration and opsonization titers (Elderly, N = 33; Adults, N = 24)

Serotype	Age	Pre-IgG concentration (μg/mL)			Post-IgG concentration (μg/mL)			Pre-Opsonic titer (OT)			Post-Opsonic titer (OT)
		GMC	95% CI	Sig	GMC	95% CI	Sig	GMT	95% CI	Sig	GMT	95% CI	Sig
4	Adult	0.43	0.32-0.59	P < 0.05	*2.21*	1.61-3.05	P < 0.05	17	6-47	NS	*1300*	694-2437	P < 0.05
	Elderly	0.27	0.22-0.34		*1.29*	0.88-1.89		10	5-20		*220*	85-569
6B	Adult	1.06	0.75-1.50	NS	*6.17*	3.51-10.85	NS	364	104-1270	NS	*8023*	5747-11202	NS
	Elderly	1.17	0.85-1.61		*7.73*	4.13-14.48		175	65-473		*5495*	3823-7898
9V	Adult	1.08	0.66-1.77	NS	*6.05*	4.22-8.68	NS	504	136-1867	NS	*6380*	3097-13140	P = 0.05
	Elderly	0.71	0.51-0.99		*5.54*	3.62-8.49		229	81-649		*4506*	2654-7649
14^a	Adult	3.02	1.56-5.86	NS	*18.7*	9.91-35.29	NS	237	71-795	NS	*6036*	4091-8907	P < 0.05
	Elderly	1.92	1.26-2.93		*10.12*	6.47-15.83		579	192-1748		*4673*	2298-9501
18C	Adult	1.10	0.72-1.67	NS	*5.8*	3.53-9.52	NS	675	236-1931	NS	*7226*	5167-10105	NS
	Elderly	0.95	0.64-1.42		*6.77*	4.42-10.37		273	104-717		*6698*	4481-10012
19A	Adult	ND		ND	ND		ND	59	21-170	NS	*2995*	1919-4675	P < 0.05
	Elderly	ND			ND			27	12-58		*556*	252-1227
19F	Adult	3.28	2.38-4.52	NS	*8.42*	5.42-13.1	NS	40	15-105	NS	*2082*	1409-3075	NS
	Elderly	2.87	2.17-3.81		*7.18*	5.18-9.95		43	19-97		*1183*	759-1843
23F	Adult	0.60	0.37-0.99	NS	*3.22*	1.91-5.41	NS	485	183-1286	NS	*3101*	2027-4746	NS
	Elderly	0.70	0.48-1.01		*5.8*	3.64-9.23		269	111-653		*3314*	2152-5101
6A	Adult	1.62	1.19-2.22	P < 0.05	2.39	1.78-3.21	NS	54	17-171	NS	*2097*	1041-4226	P < 0.05
	Elderly	3.25	2.21-4.79		4.01	2.81-5.72		17	9-36		*244*	102-587

pre vs post P < 0.05
^aFor Pn 14 OPKA was done in a limited patients due to lack of sera {Adults (N = 10), Elderly (N = 20)}

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