Skip to main content

Table 2 Number of drug holidays.

From: Modelling imperfect adherence to HIV induction therapy

FDA-approved combination

Number of drug holidays (theoretical)

Length of each holiday (days)

Minimum subsequent therapy (days)

ABC*

3TC

NVP

16

3

7

ABC*

3TC

EFV

16

3

7

TDF

3TC*

EFV

14

3.5

8.5

ddI

3TC*

EFV

14

3.5

8.5

d4T*

3TC

EFV

50

1

2.5

d4T*

3TC

NVP

50

1

2.5

ddI*

FTC

EFV

13

5

7.5

TDF

FTC*

EFV

7

6

17

TDF

FTC

NVP*

9

5

12.5

ZDV*

3TC

ABC

44

1.33

2.66

ZDV*

3TC

EFV

44

1.33

2.66

ZDV*

3TC

NVP

44

1.33

2.66

ZDV*

3TC

TDF

44

1.33

2.66

ZDV*

DLV

3TC

44

1.33

2.66

ZDV*

DLV

ddI

44

1.33

2.66

  1. Summary of all FDA-approved, PI-sparing triple-drug combinations. Drugs marked with an asterisk are the drug in their respective cocktail with the least number of doses that may theoretically be missed (see Table 1). The number of drug holidays, the length of each holiday and the minimum number of subsequent days of strict adherence is thus calculated from this drug's missable and subsequent doses.